This entry represents the TIM beta/alpha barrel found in aldolase and in related proteins. This TIM barrel usually covers the entire protein structure. Proteins containing this TIM barrel domain include class I aldolases, class I DAHP synthases, class II fructose-bisphosphate aldolases (FBP aldolases), and 5-aminolaevulinate dehydratase (a hybrid of classes I and II aldolases) [1, 2, 3].

1. Quaternary structure of aldolase leads to differences in its folding and unfolding intermediates. Biochemistry 42, 5713-21
2. X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase. Nat. Struct. Biol. 4, 1025-31
3. Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J. Mol. Biol. 343, 1019-34

This entry represents the TIM beta/alpha barrel found in aldolase and in related proteins. This T
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