This entry represents the core TIM beta/alpha barrel found in malate synthase and in related proteins such as the beta subunit of citrate lyase.

Malate synthase (2.3.3.9) catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM beta/alpha-barrel fold [1].

This entry is also represented by citrate lyase beta subunit (4.1.3.34), a component of citrate lyase (4.1.3.6), which catalyses the interconversion of citrate with acetate and oxaloacetate.

1. Crystal structure of Escherichia coli malate synthase G complexed with magnesium and glyoxylate at 2.0 A resolution: mechanistic implications. Biochemistry 39, 3156-68

This entry represents the core TIM beta/alpha barrel found in malate synthase and in related prot
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