Members of this family are O-methyltransferases, including catechol O-methyltransferase [1], caffeoyl-CoA O-methyltransferase [2] and norbelladine 4'-O-methyltransferase [3]. The family includes also bacterial O-methyltransferases that may be involved in antibiotic production [4].

1. Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation. Mol. Pharmacol. 70, 143-53
2. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiol. 137, 1009-17
3. Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus. PLoS ONE 9, e103223
4. Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus. Microbiology (Reading, Engl.) 142 ( Pt 4), 741-6

Members of this family are O-methyltransferases, including catechol O-methyltransferase [Show more...

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