The breast cancer susceptibility gene contains at its C terminus two copies ofa conserved domain that was named BRCT for BRCA1 C terminus. This domain ofabout 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control [1, 2, 3]. The BRCT domain is notlimited to the C-terminal of protein sequences and can be found in multiplecopies or in a single copy as in RAP1 and TdT. Some data [4] indicate that the BRCT domain functions as a protein-protein interaction module.

The structure of the first of the two C-terminal BRCT domains of the human DNArepair protein XRCC1 has recently been determined by X-ray crystallography[5].

1. BRCA1 protein products ... Functional motifs... Nat. Genet. 13, 266-8
2. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76
3. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30
4. Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J. 17, 6404-11

The breast cancer susceptibility gene contains at its C terminus two copies ofa conserved domain
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