The glucose-methanol-choline (GMC) oxidoreductases are FADflavoproteins oxidoreductases [1, 2].These enzymes include a variety of proteins; choline dehydrogenase (CHD), methanol oxidase (MOX) and cellobiose dehydrogenase (1.1.99.18) [3] which share a number of regions of sequence similarities. One ofthese regions, located in the N-terminal section, corresponds to the FAD ADP-binding domain. The function of the other conserved domains is not yet known.

1. GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. J. Mol. Biol. 223, 811-4
2. Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry 32, 11507-15
3. A critical review of cellobiose dehydrogenases. J. Biotechnol. 78, 93-113

The glucose-methanol-choline (GMC) oxidoreductases are FADflavoproteins oxidoreductases [Show more...

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