Gene: AT5G54770 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G54770
Transcript Identifier
AT5G54770.1
Gene Type
Coding gene
Location
Chr5 : 22246634-22247891 : positive

Family Information

Homologous gene family
HOM04D002869
(115 genes in 54 species)
specific family
Orthologous gene family
ORTHO04D003709
(104 genes in 54 species)
specific family

Descriptions

Description
thiazole biosynthetic enzyme, chloroplast (ARA6) (THI1) (THI4)
Curated Summary
Encodes a thiamine biosynthetic gene that has a dual function in thiamine biosynthesis and mitochondrial DNA damage tolerance. It appears to be involved in producing the thiazole portion of thiamine (vitamin B1). A crystal structure of the protein reveals that it forms a 2-ring homo-octamer.
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Identifiers

Type Value
Notethiazole biosynthetic enzyme, chloroplast (ARA6) (THI1) (THI4)
symbolTHI1
tidAT5G54770.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0018131
IGI
UniProtoxazole or thiazole biosynthetic process
GO:0018131
IMP, IGI
Gene Ontologyoxazole or thiazole biosynthetic process1 2
GO:0055114
IEA
Gene Ontologyoxidation-reduction process3
GO:0055114
IEA
InterProoxidation-reduction process
GO:0009409
IEP
UniProtresponse to cold
GO:0009409
IEP
Gene Ontologyresponse to cold4
GO:0009228
IGI
IEA
UniProtthiamine biosynthetic process
GO:0009228
IGI
TAS
Gene Ontologythiamine biosynthetic process2 5
GO:0009228
IEA
InterProthiamine biosynthetic process
GO:0006974
IMP
UniProtcellular response to DNA damage stimulus
GO:0006974
IMP
Gene Ontologycellular response to DNA damage stimulus5
GO:0006950
IEA
UniProtresponse to stress
GO:0006950
IEA
InterProresponse to stress
GO:0052837
IBA
IEA
UniProtthiazole biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016491
IEA
UniProtoxidoreductase activity
GO:0016491
IEA
Gene Ontologyoxidoreductase activity3
GO:0016491
IEA
InterProoxidoreductase activity
GO:0042803
IPI
UniProtprotein homodimerization activity
GO:0042803
IPI
Gene Ontologyprotein homodimerization activity6
GO:0008270
IDA
UniProtzinc ion binding
GO:0008270
IDA
Gene Ontologyzinc ion binding7
GO:0046872
IEA
UniProtmetal ion binding
GO:0005506
IBA
UniProtiron ion binding
GO:0019904
IPI
UniProtprotein domain specific binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IEA
UniProtplasma membrane
GO:0005886
IEA
Gene Ontologyplasma membrane8
GO:0009507
IDA
UniProtchloroplast
GO:0009507
IDA
ISM
Gene Ontologychloroplast9 10
GO:0005739
IDA
UniProtmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion10
GO:0009941
IDA
UniProtchloroplast envelope
GO:0009941
IDA
Gene Ontologychloroplast envelope11
GO:0009570
IDA
IEA
UniProtchloroplast stroma
GO:0009570
IDA
Gene Ontologychloroplast stroma12
GO:0009579
IDA
UniProtthylakoid
GO:0009579
IDA
Gene Ontologythylakoid13
GO:0010319
IDA
UniProtstromule
GO:0010319
IDA
Gene Ontologystromule4
GO:0005829
IBA
IEA
UniProtcytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR023753FAD/NAD(P)-binding domain
IPR027495Thiamine thiazole synthase
IPR002922Thiazole biosynthetic enzyme Thi4 family

Mapman id Description
7.2.2.1.Coenzyme metabolism.thiamine pyrophosphate biosynthesis.thiazole biosynthesis.biosynthetic protein (Thi4)