Gene: AT4G16340 (Arabidopsis thaliana)

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Gene Identifier
AT4G16340
Transcript Identifier
AT4G16340.1
Gene Type
Coding gene
Location
Chr4 : 9228773-9241060 : negative

Family Information

Homologous gene family
HOM04D003277
(100 genes in 52 species)
specific family
Orthologous gene family
ORTHO04D006077
(75 genes in 52 species)
specific family

Descriptions

Description
guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein
Curated Summary
Encodes SPIKE1 (SPK1), the lone DOCK family guanine nucleotide exchange factor (GEF) in Arabidopsis. SPK1 is a peripheral membrane protein that accumulates at, and promotes the formation of, a specialized domain of the endoplasmic reticulum (ER) termed the ER exit site (ERES). SPK1 promotes polarized growth and cell-cell adhesion in the leaf epidermis. Mutant has seedling lethal; cotyledon, leaf-shape, trichome defects.
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Identifiers

Type Value
full_nameSPIKE1
Noteguanyl-nucleotide exchange factors;GTPase binding;GTP binding protein
symbolSPK1
tidAT4G16340.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007264
IEA
UniProtsmall GTPase mediated signal transduction
GO:0007264
IEA
Gene Ontologysmall GTPase mediated signal transduction1
GO:0007264
IEA
InterProsmall GTPase mediated signal transduction
GO:0007275
IEA
UniProtmulticellular organism development
GO:0007275
IEA
Gene Ontologymulticellular organism development2
GO:0009734
IEA
UniProtauxin-activated signaling pathway
GO:0009734
IEA
Gene Ontologyauxin-activated signaling pathway2
GO:0008360
IMP
UniProtregulation of cell shape
GO:0008360
IMP
Gene Ontologyregulation of cell shape3 4
GO:0051493
IMP
UniProtregulation of cytoskeleton organization
GO:0051493
IMP
Gene Ontologyregulation of cytoskeleton organization3 4
GO:0008064
IMP
UniProtregulation of actin polymerization or depolymerization
GO:0008064
IMP
Gene Ontologyregulation of actin polymerization or depolymerization5 6
GO:0016192
IMP
UniProtvesicle-mediated transport
GO:0016192
IMP
Gene Ontologyvesicle-mediated transport7
GO:0009958
IMP
UniProtpositive gravitropism
GO:0009958
IMP
Gene Ontologypositive gravitropism8 9
GO:0010928
IMP
UniProtregulation of auxin mediated signaling pathway
GO:0010928
IMP
Gene Ontologyregulation of auxin mediated signaling pathway8 9

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005089
IDA
UniProtRho guanyl-nucleotide exchange factor activity
GO:0005089
IDA
Gene OntologyRho guanyl-nucleotide exchange factor activity10
GO:0005515
IPI
Gene Ontologyprotein binding10
GO:0005085
IEA
InterProguanyl-nucleotide exchange factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
UniProtnucleus
GO:0005634
IDA
ISM
Gene Ontologynucleus7 11
GO:0005789
IEA
UniProtendoplasmic reticulum membrane
GO:0005789
IEA
Gene Ontologyendoplasmic reticulum membrane12
GO:0005886
IDA
UniProtplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane13
GO:0005829
IDA
UniProtcytosol
GO:0005829
IDA
RCA
Gene Ontologycytosol14 15
GO:0019898
IDA
UniProtextrinsic component of membrane
GO:0019898
IDA
Gene Ontologyextrinsic component of membrane7
GO:0070971
IDA
UniProtendoplasmic reticulum exit site
GO:0070971
IDA
Gene Ontologyendoplasmic reticulum exit site7

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011989Armadillo-like helical
IPR026791Dedicator of cytokinesis
IPR010703Dedicator of cytokinesis, C-terminal
IPR027007DHR-1 domain
IPR027357DHR-2 domain

Mapman id Description
27.4.3.2.Multi-process regulation.Rop-GTPase regulatory system.RopGEF guanine nucleotide exchange factor activities.exchange factor (DHR2)