Gene: AT3G62980 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G62980
Transcript Identifier
AT3G62980.1
Gene Type
Coding gene
Location
Chr3 : 23273479-23276181 : negative

Family Information

Homologous gene family
HOM04D000492
(518 genes in 53 species)
specific family
Orthologous gene family
ORTHO04D000689
(320 genes in 53 species)
specific family

Descriptions

Description
F-box/RNI-like superfamily protein
Curated Summary
Encodes an auxin receptor that mediates auxin-regulated transcription. It contains leucine-rich repeats and an F-box and interacts with ASK1, ASK2 and AtCUL1 to form SCF-TIR1, an SCF ubiquitin ligase complex. Related to yeast Grr1p and human SKP2 proteins, involved in ubiquitin-mediated processes. Required for normal response to auxin and repressed in response to flagellin. As part of the SCF complex and in the presence of auxin, TIR1 interacts with Aux/IAA transcriptional repressor proteins and mediates their degradation. Mutations in TIR1 block auxin stimulation of flavonoid synthesis.
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Identifiers

Type Value
AliasAtTIR1
full_nameTRANSPORT INHIBITOR RESPONSE 1
symbolTIR1
tidAT3G62980.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006952
IEA
UniProtdefense response
GO:0006952
IEA
Gene Ontologydefense response1
GO:0007049
IEA
UniProtcell cycle
GO:0007049
IEA
Gene Ontologycell cycle1
GO:0009873
IEA
UniProtethylene-activated signaling pathway
GO:0009873
IEA
Gene Ontologyethylene-activated signaling pathway1
GO:0016567
IEA
Gene Ontologyprotein ubiquitination2
GO:0006511
TAS
Gene Ontologyubiquitin-dependent protein catabolic process3
GO:0009734
IMP
UniProtauxin-activated signaling pathway
GO:0009734
IMP
Gene Ontologyauxin-activated signaling pathway4
GO:0010152
IGI
UniProtpollen maturation
GO:0010152
IGI
Gene Ontologypollen maturation5
GO:0048443
IGI
UniProtstamen development
GO:0048443
IGI
Gene Ontologystamen development5
GO:0016036
IEP
UniProtcellular response to phosphate starvation
GO:0016036
IEP
Gene Ontologycellular response to phosphate starvation6
GO:0009733
IMP
UniProtresponse to auxin
GO:0009733
IMP
Gene Ontologyresponse to auxin7 8
GO:0010311
IMP
UniProtlateral root formation
GO:0010311
IMP
Gene Ontologylateral root formation9
GO:0048527
IEA
PLAZA Tree-based Orthologylateral root development AT1G12820
GO:0048589
IEA
PLAZA Tree-based Orthologydevelopmental growth AT4G03190
GO:0045014
IEA
PLAZA Tree-based Orthologynegative regulation of transcription by glucose AT4G03190
GO:0071249
IEA
PLAZA Tree-based Orthologycellular response to nitrate AT1G12820
GO:0080022
IEA
PLAZA Tree-based Orthologyprimary root development AT1G12820

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IC
UniProtubiquitin-protein transferase activity
GO:0004842
ISS
IC
Gene Ontologyubiquitin-protein transferase activity10 11
GO:0005515
IPI
Gene Ontologyprotein binding11
GO:0005515
IEA
InterProprotein binding
GO:0010011
IDA
UniProtauxin binding
GO:0010011
IDA, IGI
Gene Ontologyauxin binding12 13
GO:0038198
IDA
UniProtauxin receptor activity
GO:0038198
IDA
Gene Ontologyauxin receptor activity12
GO:0000822
IDA
UniProtinositol hexakisphosphate binding
GO:0000822
IDA
Gene Ontologyinositol hexakisphosphate binding13

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
UniProtnucleus
GO:0005634
ISM
IEA
Gene Ontologynucleus14 15
GO:0000151
IDA
Gene Ontologyubiquitin ligase complex11
GO:0019005
IDA
UniProtSCF ubiquitin ligase complex
GO:0019005
IDA
Gene OntologySCF ubiquitin ligase complex11
GO:0005774
IEA
PLAZA Tree-based Orthologyvacuolar membrane AT3G26810
GO:0043224
IEA
PLAZA Tree-based Orthologynuclear SCF ubiquitin ligase complex AT4G03190

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR032675Leucine-rich repeat domain, L domain-like
IPR001810F-box domain

Mapman id Description
11.2.2.1.1.Phytohormone action.auxin.perception and signal transduction.receptor complex.component TIR1/AFB
19.2.2.8.1.4.6.Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX