Dicots PLAZA 4.5 gene overview : AT3G48750

Gene: AT3G48750 (Arabidopsis thaliana)

Overview

Gene Identifier: AT3G48750
Transcript Identifier: AT3G48750.1
Gene Type: Coding gene
Location: Chr3 : 18072238-18074296 : positive

Family Information

Homologous gene family: HOM04D000083
(1914 genes in 55 species)
specific family
Orthologous gene family: ORTHO04D003926
(99 genes in 55 species)
specific family

Descriptions

Description: cell division control 2

Curated Summary: A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.

Identifiers

Type	Value
Alias	CDC2A,CDC2AAT,CDK2,CDKA1,CDKA;1
symbol	CDC2
tid	AT3G48750.1

Toolbox

Biological Process

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0000226	IBA	UniProt	microtubule cytoskeleton organization
GO:0000226	IBA	Gene Ontology	microtubule cytoskeleton organization	1
GO:0006281	IBA	UniProt	DNA repair
GO:0006281	IBA	Gene Ontology	DNA repair	1
GO:0007346	IBA	UniProt	regulation of mitotic cell cycle
GO:0007346	IBA	Gene Ontology	regulation of mitotic cell cycle	1
GO:0010468	IBA	UniProt	regulation of gene expression
GO:0010468	IBA	Gene Ontology	regulation of gene expression	1
GO:0016572	IBA	UniProt	histone phosphorylation
GO:0016572	IBA	Gene Ontology	histone phosphorylation	1
GO:0030154	IBA	Gene Ontology	cell differentiation	1
GO:0044772	IBA	UniProt	mitotic cell cycle phase transition
GO:0044772	IBA	Gene Ontology	mitotic cell cycle phase transition	1
GO:0042023	IMP	UniProt	DNA endoreduplication
GO:0042023	IMP	Gene Ontology	DNA endoreduplication	2
GO:0009555	IMP	UniProt	pollen development
GO:0009555	IMP	Gene Ontology	pollen development	3
GO:0008284	IMP	UniProt	positive regulation of cell proliferation
GO:0008284	IMP	Gene Ontology	positive regulation of cell proliferation	4
GO:0009793	IMP	UniProt	embryo development ending in seed dormancy
GO:0009793	IMP	Gene Ontology	embryo development ending in seed dormancy	4
GO:0040020	IMP	UniProt	regulation of meiotic nuclear division
GO:0040020	IMP	Gene Ontology	regulation of meiotic nuclear division	5
GO:0048229	IMP	UniProt	gametophyte development
GO:0048229	IMP	Gene Ontology	gametophyte development	6
GO:0008356	IGI	UniProt	asymmetric cell division
GO:0008356	IGI	Gene Ontology	asymmetric cell division	7
GO:0010235	IMP	UniProt	guard mother cell cytokinesis
GO:0010235	IMP	Gene Ontology	guard mother cell cytokinesis	8 9
GO:0010444	IMP	UniProt	guard mother cell differentiation
GO:0010444	IMP	Gene Ontology	guard mother cell differentiation	8 9
GO:0098725	IMP	UniProt	symmetric cell division
GO:0098725	IMP	Gene Ontology	symmetric cell division	8 9
GO:1902806	IMP	UniProt	regulation of cell cycle G1/S phase transition
GO:1902806	IMP	Gene Ontology	regulation of cell cycle G1/S phase transition	8 9
GO:0000911	IMP	UniProt	cytokinesis by cell plate formation
GO:0000911	IMP	Gene Ontology	cytokinesis by cell plate formation	10
GO:0009409	IEP	UniProt	response to cold
GO:0009409	IEP	Gene Ontology	response to cold	11
GO:0006468	IEA	InterPro	protein phosphorylation

Molecular Function

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0004693	ISS	UniProt	cyclin-dependent protein serine/threonine kinase activity
GO:0004693	ISS, IBA	Gene Ontology	cyclin-dependent protein serine/threonine kinase activity	1 12
GO:0005524	IEA	UniProt	ATP binding
GO:0005524	IEA	Gene Ontology	ATP binding	13
GO:0005524	IEA	InterPro	ATP binding
GO:0008353	IEA	UniProt	RNA polymerase II carboxy-terminal domain kinase activity
GO:0008353	IEA	Gene Ontology	RNA polymerase II carboxy-terminal domain kinase activity	14
GO:0016301	IMP	UniProt	kinase activity
GO:0016301	IMP ISS	Gene Ontology	kinase activity	5 15
GO:0005515	IPI	Gene Ontology	protein binding	16
GO:0004672	IDA	UniProt	protein kinase activity
GO:0004672	IDA	Gene Ontology	protein kinase activity	17
GO:0004672	IEA	InterPro	protein kinase activity

Cellular Component

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005634	IDA	UniProt	nucleus
GO:0005634	IDA ISM	Gene Ontology	nucleus	18 19
GO:0072686	IBA	UniProt	mitotic spindle
GO:0072686	IBA	Gene Ontology	mitotic spindle	1
GO:0005886	IDA	UniProt	plasma membrane
GO:0005886	IDA	Gene Ontology	plasma membrane	20
GO:0005829	IDA	UniProt	cytosol
GO:0005829	IDA	Gene Ontology	cytosol	19
GO:0005737	IDA	UniProt	cytoplasm
GO:0005737	IDA	Gene Ontology	cytoplasm	21
GO:0009574	TAS	UniProt	preprophase band
GO:0009574	TAS	Gene Ontology	preprophase band	22
GO:0010005	IDA	UniProt	cortical microtubule, transverse to long axis
GO:0010005	IDA	Gene Ontology	cortical microtubule, transverse to long axis	22

Color Legend

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR017441	Protein kinase, ATP binding site
IPR011009	Protein kinase-like domain

Mapman id	Description
13.1.1.2.1	.Cell cycle organisation.cell cycle control.cyclin-dependent regulation.cyclin-dependent protein kinase complex.catalytic component CDKA
18.4.3.1.1	.Protein modification.phosphorylation.CMGC protein kinase superfamily.CDK protein kinase families.protein kinase (CDKA)

Gene: AT3G48750 (Arabidopsis thaliana)

Overview

Family Information

Descriptions

Identifiers

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Biological Process

Molecular Function

Cellular Component

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