The WPP domain is thought to be exclusively found in plants. The WPP stands for a tryptophan-proline-proline motif that is highly conserved in the domain [1]. The WPP domain is known to direct RanGAP (Ran GTPase-activating protein) to the nuclear envelope [2]. RanGAP is an accessory protein for the small signaling GTPase Ran, which is involved in nucleocytoplasmic transport. Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1) [3], WPP1 [3] and WPP2 [4].

1. A novel link between ran signal transduction and nuclear envelope proteins in plants. Plant Physiol. 124, 1507-10
2. A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim. Proc. Natl. Acad. Sci. U.S.A. 98, 15377-82
3. Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division. Plant Cell 16, 3260-73

The WPP domain is thought to be exclusively found in plants. The WPP stands for a tryptophan-prol
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