The IPT (Ig-like, plexins, transcription factors) domain has an immunoglobulin like fold [1]. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering) [2].

1. Domains in plexins: links to integrins and transcription factors. Trends Biochem. Sci. 24, 261-3
2. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol. Cell. Biol. 16, 5518-26

The IPT (Ig-like, plexins, transcription factors) domain has an immunoglobulin like fold [Show more...

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