Proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins [Reid M.E., Lomas-Francis C. The Blood Group Antigen Facts Book Academic Press, London / San Diego, (1997)]. The RH(CE) polypeptide (Rhesus C/E antigens) and RH(D) polypeptide (Rhesus D antigen) belong to the Rh blood group system and are associated with antigens that include C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar, VS, D(w), cE, amongst others.

The Rh (Rhesus) blood group system is important in clinical medicine byvirtue of being involved in haemolytic disease of the newborn, transfusionreactions, autoimmune haemolytic anaemias, and haemolytic reactions of nonimmune origin [1]. The RH locus from RH(D)-positive donors contains 2homologous structural genes, one of which encodes the D protein thatcarries the major antigen of the Rh system. Hydropathy analysis of the RhD gene product reveals 13 hydrophobic domains, all of which have been assumed to be transmembrane (TM) [2].

1. Molecular cloning and primary structure of the human blood group RhD polypeptide. Proc. Natl. Acad. Sci. U.S.A. 89, 10925-9

Proteins in this group are responsible for the molecular basis of the blood group antigens, surfa
Show more...

Download genes (select columns to include)