This entry groups metazoan phosphatidylethanolamine-binding proteins, carboxypeptidase Y inhibitor from Saccharomyces cerevisiae (Baker's yeast) (P14306), and homologues from plants which function in flower development. The members of this family belong to MEROPS proteinase inhibitor family I51, clan I-.

In metazoa the phosphatidylethanolamine-binding proteins are an around 200 residue and found in a variety of tissues [1]. They bind hydrophobic ligands, such as phosphatidylethanolamine, but also seems [2] to bind nucleotides such as GTP and FMN, it has been suggested that they could act in membrane remodelling during growth and maturation.

In plants, the phosphatidylethanolamine-binding protein homologues, include:

• CENTRORADIALIS (CEN) [3]
• SELF PRUNING (SP) [4]
• TERMINAL FLOWER 1 (TFL1)
• FLOWERING LOCUS T (FT)
• MOTHER OF FT AND TFL1 (MTF) [5]

In Arabidopsis thaliana (Mouse-ear cress), FT together with LEAFY (LFY), IPR002910, promote flowering and are positively regulated by the transcription factor CONSTANS (CO), IPR002926. Loss of FT causes delay in flowering, whereas over expression of FT results in precocious flowering independent of CO or photoperiod. FT acts in part downstream of CO and mediates signals for flowering in an antagonistic manner with its homologous gene, TERMINAL FLOWER1 (TFL1) [6].

1. Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. J. Mol. Evol. 39, 655-60
2. From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. FEBS Lett. 369, 22-6
3. The delayed terminal flower phenotype is caused by a conditional mutation in the CENTRORADIALIS gene of snapdragon. Plant Physiol. 126, 1031-41
4. The SELF-PRUNING gene family in tomato. Plant Mol. Biol. 52, 1215-22
5. Acceleration of flowering by overexpression of MFT (MOTHER OF FT AND TFL1). Mol. Cells 17, 95-101
6. A pair of related genes with antagonistic roles in mediating flowering signals. Science 286, 1960-2

This entry groups metazoan phosphatidylethanolamine-binding proteins, carboxypeptidase Y inhibito
Show more...

Download genes (select columns to include)