Alpha-actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures [1]. The actin-binding domain of alpha-actinin seems to reside in the first 250 residues of the protein. A similar actin-binding domain has been found in the N-terminal region of many different actin-binding proteins [2, 3], like the beta chain of spectrin (or fodrin), dystrophin, the slime mold gelation factor (or ABP-120), filamin and fimbrin.

1. Actin-binding proteins are conserved from slime molds to man. Dev. Genet. 9, 521-30
2. Modular organization of actin crosslinking proteins. Trends Biochem. Sci. 16, 87-92
3. Structure and evolution of the actin crosslinking proteins. Bioessays 13, 219-26

Alpha-actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of
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