The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger)[2] domain is present near the N terminus of a fraction of zinc finger(IPR007087) proteins and in proteins that contain the IPR006652 motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation [3].The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule [3].POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT [4, 5, 6].The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

1. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 91, 10717-21
2. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8, 1664-77
3. Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. U.S.A. 95, 12123-8
4. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6, 1495-503
5. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 17, 2473-84
6. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J. Biol. Chem. 273, 27695-702

The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc fi
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