Gene: AT5G58230 (Arabidopsis thaliana)

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Gene Identifier
AT5G58230
Transcript Identifier
AT5G58230.1
Gene Type
Coding gene
Location
5 : 23556112-23557994 : positive

Family

Gene family
HOM03M000152
(317 genes in 16 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
Transducin/WD40 repeat-like superfamily protein
Curated Summary
Encodes a WD-40 repeat containing protein that functions in chromatin assembly as part of the CAF1 and FIE complex. Mutants exhibit parthenogenetic development that includes proliferation of unfertilized endosperm and embryos. In heterozygous plants 50% of embryos abort. Of the aborted embryos the early aborted class are homozygous and the later aborting lass are heterozygotes in which the defective allele is maternally transmitted. Other phenotypes include defects in ovule morphogenesis and organ initiation,as well as increased levels of heterochromatic DNA. MSI1 is needed for the transition to flowering. In Arabidopsis, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. Mutations in FAS1 or FAS2 lead to increased frequency of homologous recombination and T-DNA integration in Arabidopsis. In the ovule, the MSI1 transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization. MSI is biallelically expressed, the paternall allele is expressed in the endosperm and embryo and is not imprinted. MSI1 forms a complex with RBR1 that is required for activation of the imprinted genes FIS2 and FWA. This activation is mediated by MSI1/RBR1 mediated repression of MET1.
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Identifiers

Identifier Name
aliasMATERNAL EFFECT EMBRYO ARREST 70
aliasMSI1
aliasMULTICOPY SUPRESSOR OF IRA1
aliasMEE70
aliasARABIDOPSIS MULTICOPY SUPRESSOR OF IRA1
aliasATMSI1
uniprotO22467

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0007275IMPGene Ontologymulticellular organismal development1
GO:0016568IMPGene Ontologychromatin modification1
GO:0009793IMPUniProtembryo development ending in seed dormancy1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0031507IMP, RCA, UniProtheterochromatin assembly1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0009909IMP, RCA, UniProtregulation of flower development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0008283IMPUniProtcell proliferation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0010026IMPUniProttrichome differentiation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0048366IMPUniProtleaf development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0010214IMPUniProtseed coat development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0048316IMPGene Ontologyseed development1
GO:0009555IMP, IGIUniProtpollen development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0045787IGI, RCA, UniProtpositive regulation of cell cycle1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0006349IPIUniProtregulation of gene expression by genetic imprinting1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0006275RCAGene Ontologyregulation of DNA replication1
GO:0009965RCAGene Ontologyleaf morphogenesis1
GO:0010389RCAGene Ontologyregulation of G2/M transition of mitotic cell cycle1
GO:0016570RCAGene Ontologyhistone modification1
GO:0048449RCAGene Ontologyfloral organ formation1
GO:0006260IEAUniProtDNA replication1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0009908IEAUniProtflower development1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0006355IEAUniProtregulation of transcription, DNA-dependent1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0006508IEAPLAZA HomologyproteolysisHOM03M000152

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0008234IEAPLAZA Homologycysteine-type peptidase activityHOM03M000152

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISM, TASGene Ontologynucleus1 2
GO:0043234IPIGene Ontologyprotein complex1
GO:0009507IDAUniProtchloroplast1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0080008ISSUniProtCul4-RING ubiquitin ligase complex1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005677IDAUniProtchromatin silencing complex1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR020472G-protein beta WD-40 repeat
IPR001680WD40 repeat
IPR017986WD40-repeat-containing domain
IPR022052Histone-binding protein RBBP4, N-terminal
IPR015943WD40/YVTN repeat-like-containing domain
IPR019775WD40 repeat, conserved site

Mapman id Description
33.99development.unspecified
No SignalP domains detected for this gene.