Gene: AT5G56290 (Arabidopsis thaliana)

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Gene Identifier
AT5G56290
Transcript Identifier
AT5G56290.1
Gene Type
Coding gene
Location
5 : 22786655-22791972 : positive

Family

Gene family
HOM03M004219
(22 genes in 16 species)
specific family

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Descriptions

Description
peroxin 5
Curated Summary
Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal 'SKL' targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions.
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Identifiers

Identifier Name
aliasperoxin 5
aliasARABIDOPSIS PEROXIN 5
aliasEMBRYO DEFECTIVE 2790
aliasEMB2790
aliasATPEX5
aliasPEX5
uniprotQ9FMA3

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006625IGI, ISSGene Ontologyprotein targeting to peroxisome1 2
GO:0016558IBA, RCA, UniProtprotein import into peroxisome matrix1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0009733IMPUniProtresponse to auxin1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0006635RCAGene Ontologyfatty acid beta-oxidation1
GO:0006869RCAGene Ontologylipid transport1
GO:0006891RCAGene Ontologyintra-Golgi vesicle-mediated transport1
GO:0009062RCAGene Ontologyfatty acid catabolic process1
GO:0010351RCAGene Ontologylithium ion transport1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005052IBA, ISS, UniProtperoxisome matrix targeting signal-1 binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0005515IPI, IEAGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0005778IBAUniProtperoxisomal membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005829IBAUniProtcytosol1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011990Tetratricopeptide-like helical
IPR019734Tetratricopeptide repeat
IPR001440Tetratricopeptide TPR1
IPR013105Tetratricopeptide TPR2
IPR024111Peroxisomal targeting signal 1 receptor family
IPR013026Tetratricopeptide repeat-containing domain

Mapman id Description
29.3.5protein.targeting.peroxisomes
No SignalP domains detected for this gene.