Gene: AT5G55300 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
5 : 22424701-22429045 : negative


Gene family
(24 genes in 16 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

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DNA topoisomerase I alpha
Curated Summary
Encodes a type-I DNA topoisomerase I. Disruptions in this gene affect phyllotaxis and plant architecture suggesting that the gene plays a critical role in the maintenance of a regular pattern of organ initiation. Isolated as a protein oxidized during seed germination; proteomics approach revealed differences in de novo synthesis levels of this protein in condition with vs. without salicylic acid in the period from 0 to 40 hrs. following seed imbibition. Functions in stem cell maintenance at all stages of shoot and floral meristems and in the regulation of gene silencing.
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Identifier Name
aliasMGOUN 1
aliasDNA topoisomerase I alpha





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006259ISSGene OntologyDNA metabolic process1
GO:0006265IEA, IBA, ISSUniProtDNA topological change1 2 3 4 5 6
GO:0010016IMPGene Ontologyshoot system morphogenesis1
GO:0048439IMPGene Ontologyflower morphogenesis1
GO:0048645IMPGene Ontologyorgan formation1
GO:0006338IGIGene Ontologychromatin remodeling1
GO:0009933IMP, RCAGene Ontologymeristem structural organization1 2
GO:0019827IGIGene Ontologystem cell maintenance1
GO:0001676RCAGene Ontologylong-chain fatty acid metabolic process1
GO:0002213RCAGene Ontologydefense response to insect1
GO:0006633RCAGene Ontologyfatty acid biosynthetic process1
GO:0009640RCAGene Ontologyphotomorphogenesis1
GO:0009793IMP, RCAGene Ontologyembryo development ending in seed dormancy1 2
GO:0009845RCAGene Ontologyseed germination1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0010162RCAGene Ontologyseed dormancy process1
GO:0010182RCAGene Ontologysugar mediated signaling pathway1
GO:0010228RCAGene Ontologyvegetative to reproductive phase transition of meristem1
GO:0016567RCAGene Ontologyprotein ubiquitination1
GO:0019915RCAGene Ontologylipid storage1
GO:0050826RCAGene Ontologyresponse to freezing1
GO:0009791IMPGene Ontologypost-embryonic development1
GO:0009965IMPGene Ontologyleaf morphogenesis1
GO:0010075IMPGene Ontologyregulation of meristem growth1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003917IEA, IGI, ISSUniProtDNA topoisomerase type I activity1 2 3 4 5 6
GO:0031490IBAGene Ontologychromatin DNA binding1
GO:0005515IPIGene Ontologyprotein binding1
GO:0005524IEAUniProtATP binding1 2 3 4
GO:0003677IEAUniProtDNA binding1 2 3 4
GO:0003918IEAUniProtDNA topoisomerase type II (ATP-hydrolyzing) activity1 2 3 4
GO:0061505IEAPLAZA HomologyDNA topoisomerase II activityHOM03M003833

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5
GO:0005694IEAUniProtchromosome1 2 3 4

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011010DNA breaking-rejoining enzyme, catalytic core
IPR013500DNA topoisomerase I, catalytic core, eukaryotic-type
IPR013499DNA topoisomerase I, eukaryotic-type
IPR001631DNA topoisomerase I
IPR008336DNA topoisomerase I, DNA binding, eukaryotic-type
IPR014727DNA topoisomerase I, catalytic core, alpha/beta subdomain
IPR013030DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type
IPR014711DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
IPR025834Topoisomerase I C-terminal domain
IPR013034DNA topoisomerase I, domain 1
IPR018521DNA topoisomerase I, active site

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.