Gene: AT5G45307 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G45307
Transcript Identifier
AT5G45307.1
Gene Type
RNA gene
Location
5 : 18358805-18358893 : negative

Family

No gene family defined for this gene.

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Descriptions

Description
MIR168/MIR168B; miRNA
Curated Summary
Encodes a microRNA that targets AGO1. MicroRNAs are regulatory RNAs with a mature length of ~21-nucleotides that are processed from hairpin precursors by Dicer-like enzymes. MicroRNAs can negatively regulate gene expression by attenuating translation or by directing mRNA cleavage.Mature sequence: UCGCUUGGUGCAGGUCGGGAA. MIR168a is highly expressed and predominantly produces a 21-nt miR168 species. By contrast, MIR168b is expressed at low levels and produces an equal amount of 21- and 22-nt miR168 species. Only the 21-nt miR168 is preferentially stabilized by AGO1, and consequently, the accumulation of the 22-nt but not the 21-nt miR168 is reduced when DCL1 activity is impaired. mir168a mutants with strongly reduced levels of 21-nt miR168 are viable but exhibit developmental defects, particularly during environmentally challenging conditions.

Identifiers

Identifier Name
aliasMICRORNA 168
aliasMIR168
aliasMIR168B
aliasmicroRNA168B

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  • ...the local gene organization for homologous genes.
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  • ...the conserved binding sites (upstream/downstream,intron)

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0035195IDA, TASGene Ontologygene silencing by miRNA1 2

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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No InterPro domains detected for this gene.
Mapman id Description
32micro RNA, natural antisense etc
No SignalP domains detected for this gene.