Gene: AT5G22220 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G22220
Transcript Identifier
AT5G22220.2
Gene Type
Coding gene
Location
5 : 7360749-7364120 : positive

Family

Gene family
HOM03M001192
(61 genes in 16 species)
specific family
Subfamily
ORTHO03M004340
(7 genes in 6 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
E2F transcription factor 1
Curated Summary
Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. Binds DPA and RBR1 proteins. Expressed throughout the cell cycle. Abundance increased by auxin through stabilization of the protein. Elevates CDK levels and activity, even under hormone-free conditions. Promotes cell division and shortens cell doubling time, inhibits cell growth. Transgenic plants overexpressing AtE2Fa contained an increased level of AtE2Fb transcripts that is paralleled by an increase in the amount of the AtE2Fb protein, suggesting that AtE2Fb expression might actually be up-regulated by the AtE2Fa transcription factor.
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Identifiers

Identifier Name
aliasE2F1
aliasE2FB
aliasATE2FB
aliasE2F transcription factor 1
uniprotQ9FV71

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006355ISS, IEAGene Ontologyregulation of transcription, DNA-dependent1
GO:0045893IDAUniProtpositive regulation of transcription, DNA-dependent1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0009733IEPUniProtresponse to auxin1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0051302IMP, RCA, UniProtregulation of cell division1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0051446IMPUniProtpositive regulation of meiotic cell cycle1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0010090IMP, RCA, UniProttrichome morphogenesis1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0008284IMPUniProtpositive regulation of cell proliferation1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0006396RCAGene OntologyRNA processing1
GO:0042023RCAGene OntologyDNA endoreduplication1
GO:0007049IEAUniProtcell cycle1 2 3 4 5 6 7 8 9 10 11 12 13
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9 10 11 12 13
GO:2001141IEAPLAZA Homologyregulation of RNA biosynthetic processHOM03M001192

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003700IDA, ISSIEA, UniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005515IPIGene Ontologyprotein binding1
GO:0003677IDAUniProtDNA binding1 2 3 4 5 6 7 8 9 10 11 12 13 14

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005667IEA, ISSUniProttranscription factor complex1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0005737IDAUniProtcytoplasm1 2 3 4 5 6 7 8 9 10 11 12 13 14

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003316Transcription factor E2F/dimerisation partner (TDP)
IPR011991Winged helix-turn-helix DNA-binding domain
IPR015633E2F Family

Mapman id Description
27.3.18RNA.regulation of transcription.E2F/DP transcription factor family
No SignalP domains detected for this gene.
DatabaseType
PlnTFDBE2F-DP
PlantTFDBE2F/DP