Gene: AT5G16850 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G16850
Transcript Identifier
AT5G16850.1
Gene Type
Coding gene
Location
5 : 5538323-5543444 : negative

Family

Gene family
HOM03M004526
(21 genes in 15 species)
specific family
Subfamily
ORTHO03M004836
(7 genes in 7 species)
specific family

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Descriptions

Description
telomerase reverse transcriptase
Curated Summary
Encodes the catalytic subunit of telomerase reverse transcriptase. Involved in telomere homeostasis. Homozygous double mutants with ATR show gross morphological defects over a period of generations. TERT shows Class II telomerase activity in vitro, indicating that it can initiate de novo telomerase synthesis on non-telomeric DNA, often using a preferred position within the telomerase-bound RNA.
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Identifiers

Identifier Name
aliasTERT
aliastelomerase reverse transcriptase
aliasATTERT
uniprotQ9SPU7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0007004IMP, IGIUniProttelomere maintenance via telomerase1 2 3 4 5 6 7 8 9 10 11
GO:0007000IMPUniProtnucleolus organization1 2 3 4 5 6 7 8 9 10
GO:0050000IMPUniProtchromosome localization1 2 3 4 5 6 7 8 9 10
GO:0051276IGIGene Ontologychromosome organization1
GO:0000723IDAGene Ontologytelomere maintenance1
GO:0006278IEAInterProRNA-dependent DNA replication

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003721IEA, ISSUniProttelomeric template RNA reverse transcriptase activity1 2 3 4 5 6 7 8 9 10
GO:0003720IDAUniProttelomerase activity1 2 3 4 5 6 7 8 9 10
GO:0005515IPIGene Ontologyprotein binding1
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6 7 8 9
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6 7 8 9
GO:0003723IEAUniProtRNA binding1 2 3 4 5 6 7 8 9
GO:0003964IEAInterProRNA-directed DNA polymerase activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0000781IEAUniProtchromosome, telomeric region1 2 3 4 5 6 7 8 9

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000477Reverse transcriptase
IPR003545Telomere reverse transcriptase
IPR021891Telomerase ribonucleoprotein complex - RNA-binding domain

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.