Gene: AT5G13570 (Arabidopsis thaliana)

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Gene Identifier
AT5G13570
Transcript Identifier
AT5G13570.2
Gene Type
Coding gene
Location
5 : 4367532-4369992 : positive

Family

Gene family
HOM03M004546
(21 genes in 16 species)
specific family

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Descriptions

Description
decapping 2
Curated Summary
Encodes DCP2 with mRNA decapping activity. DCP2 forms a mRNA decapping complex with DCP1 (At1g08370) and VCS (VARICOSE) (At3g13300). Recombinant DCP2 is enzymatically active in vitro, generating from capped mRNAs m7GDP, and 5?-phosphorylated mRNAs. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP1.
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Identifiers

Identifier Name
aliasITS1
aliasDCP2
aliasTDT
aliasINCREASED TRANSGENE SILENCING 1
aliasTRIDENT
aliasdecapping 2
aliasATDCP2
uniprotQ8GW31

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0031087IDAGene Ontologydeadenylation-independent decapping of nuclear-transcribed mRNA1
GO:0006402IMPGene OntologymRNA catabolic process1
GO:0009791IMPGene Ontologypost-embryonic development1
GO:0010072IMPUniProtprimary shoot apical meristem specification1 2 3 4 5 6 7 8 9
GO:0000956RCAGene Ontologynuclear-transcribed mRNA catabolic process1
GO:0006635RCAGene Ontologyfatty acid beta-oxidation1
GO:0016558RCAGene Ontologyprotein import into peroxisome matrix1
GO:0044265RCAGene Ontologycellular macromolecule catabolic process1
GO:0016441IMPGene Ontologyposttranscriptional gene silencing1
GO:0006397IEAUniProtmRNA processing1 2 3 4 5 6 7 8

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016787IEA, ISSUniProthydrolase activity1 2 3 4 5 6 7 8 9
GO:0005515IPIGene Ontologyprotein binding1
GO:0050072IDAGene Ontologym7G(5')pppN diphosphatase activity1
GO:0042803IPIGene Ontologyprotein homodimerization activity1
GO:0000287IDAUniProtmagnesium ion binding1 2 3 4 5 6 7 8 9
GO:0003729IDAGene OntologymRNA binding1
GO:0030145IDA, IEA, UniProtmanganese ion binding1 2 3 4 5 6 7 8 9
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8
GO:0003723IEAUniProtRNA binding1 2 3 4 5 6 7 8

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0000932IEA, IDA, NASUniProtcytoplasmic mRNA processing body1 2 3 4 5 6 7 8 9 10
GO:0005737IDAGene Ontologycytoplasm1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000086NUDIX hydrolase domain
IPR015797NUDIX hydrolase domain-like
IPR007722mRNA decapping protein 2, Box A

Mapman id Description
27.1RNA.processing
33.99development.unspecified
No SignalP domains detected for this gene.