Gene: AT5G11390 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
5 : 3633971-3636418 : positive


Gene family
(45 genes in 16 species)
specific family

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WPP domain-interacting protein 1
Curated Summary
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
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Identifier Name
aliasWPP domain-interacting protein 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006913RCAGene Ontologynucleocytoplasmic transport1
GO:0048527RCAGene Ontologylateral root development1
GO:0046907IEAPLAZA Homologyintracellular transportHOM03M001761
GO:0006886IEAPLAZA Homologyintracellular protein transportHOM03M001761

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1
GO:0008536IEAPLAZA HomologyRan GTPase bindingHOM03M001761

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005635IDAUniProtnuclear envelope1 2 3 4 5
GO:0016021IEAUniProtintegral to membrane1 2 3 4
GO:0031965IEAUniProtnuclear membrane1 2 3 4

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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No InterPro domains detected for this gene.
Mapman id Description
35.2not assigned.unknown
No SignalP domains detected for this gene.