Gene: AT5G10480 (Arabidopsis thaliana)

Overview top

Gene Identifier
Transcript Identifier
Gene Type
Coding gene
5 : 3298047-3300048 : negative


Gene family
(43 genes in 16 species)
specific family

Loading...please wait


Protein-tyrosine phosphatase-like, PTPLA
Curated Summary
Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. Localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation. Based on complementation of yeast mutant PAS2 has acyl-CoA dehydratase activity. It interacts with CER10, a component of the microsomal fatty acid elongase complex, suggesting a role in synthesis of VLCFAs (very long chain fatty acids).
Show more...


Identifier Name





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0048640IMPGene Ontologynegative regulation of developmental growth1
GO:0050732IMPGene Ontologynegative regulation of peptidyl-tyrosine phosphorylation1
GO:0051302IMPGene Ontologyregulation of cell division1
GO:0042761IMPGene Ontologyvery long-chain fatty acid biosynthetic process1
GO:0000271RCAGene Ontologypolysaccharide biosynthetic process1
GO:0009825RCAGene Ontologymultidimensional cell growth1
GO:0009932RCAGene Ontologycell tip growth1
GO:0010817RCAGene Ontologyregulation of hormone levels1
GO:0019344RCAGene Ontologycysteine biosynthetic process1
GO:0043481RCAGene Ontologyanthocyanin accumulation in tissues in response to UV light1
GO:0048767RCAGene Ontologyroot hair elongation1
GO:0071555RCAGene Ontologycell wall organization1
GO:0030154IMPGene Ontologycell differentiation1
GO:0006633IEAUniProtfatty acid biosynthetic process1 2 3 4 5 6 7 8 9
GO:0007275IEAUniProtmulticellular organismal development1 2 3 4 5 6 7 8 9

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004725ISSGene Ontologyprotein tyrosine phosphatase activity1
GO:0080023IGIGene Ontology3R-hydroxyacyl-CoA dehydratase activity1
GO:0016829IEAUniProtlyase activity1 2 3 4 5 6 7 8 9

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005739ISMGene Ontologymitochondrion1
GO:0005634IEA, IDAUniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0005829IDAGene Ontologycytosol1
GO:0009923IPIGene Ontologyfatty acid elongase complex1
GO:0016021IEA, IDAUniProtintegral to membrane1 2 3 4 5 6 7 8 9 10
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0005789IEAUniProtendoplasmic reticulum membrane1 2 3 4 5 6 7 8 9

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
InterPro Description
IPR007482Protein-tyrosine phosphatase-like, PTPLA

Mapman id Description
29.4protein.postranslational modification
No SignalP domains detected for this gene.