Gene: AT5G08280 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G08280
Transcript Identifier
AT5G08280.1
Gene Type
Coding gene
Location
5 : 2663763-2665596 : negative

Family

Gene family
HOM03M004129
(23 genes in 16 species)
specific family

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Descriptions

Description
hydroxymethylbilane synthase
Curated Summary
Encodes a protein with porphobilinogen deaminase activity. This protein is targeted to the chloroplast. Mutants spontaneously develop chlorotic leaf lesions in the absence of pathogen attack, resembling the phenotype of lesion-mimic mutants.
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Identifiers

Identifier Name
aliasRUGOSA 1
aliashydroxymethylbilane synthase
aliasRUG1
aliasHEMC
uniprotQ43316

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0042742IEP, RCA, UniProtdefense response to bacterium1 2 3 4 5 6 7 8 9
GO:0006098RCAGene Ontologypentose-phosphate shunt1
GO:0006364RCAGene OntologyrRNA processing1
GO:0006744RCAGene Ontologyubiquinone biosynthetic process1
GO:0009073RCAGene Ontologyaromatic amino acid family biosynthetic process1
GO:0009409RCAGene Ontologyresponse to cold1
GO:0009697RCAGene Ontologysalicylic acid biosynthetic process1
GO:0009814RCAGene Ontologydefense response, incompatible interaction1
GO:0009965RCAGene Ontologyleaf morphogenesis1
GO:0015995TAS, RCAUniProtchlorophyll biosynthetic process1 2 3 4 5 6 7 8 9
GO:0019288RCAGene Ontologyisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway1
GO:0019344RCAGene Ontologycysteine biosynthetic process1
GO:0019684RCAGene Ontologyphotosynthesis, light reaction1
GO:0030154RCAGene Ontologycell differentiation1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1
GO:0006779TASGene Ontologyporphyrin-containing compound biosynthetic process1
GO:0018160IEAUniProtpeptidyl-pyrromethane cofactor linkage1 2 3 4 5 6 7
GO:0006782IEAUniProtprotoporphyrinogen IX biosynthetic process1 2 3 4 5 6 7
GO:0033014IEAInterProtetrapyrrole biosynthetic process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004418IDA, IMPIEA, UniProthydroxymethylbilane synthase activity1 2 3 4 5 6 7 8 9

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0009507IDA, ISMGene Ontologychloroplast1 2
GO:0009941IDAUniProtchloroplast envelope1 2 3 4 5 6 7 8
GO:0009570IDAUniProtchloroplast stroma1 2 3 4 5 6 7 8
GO:0048046IDAUniProtapoplast1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR022419Porphobilinogen deaminase, dipyrromethane cofactor binding site
IPR000860Tetrapyrrole biosynthesis, hydroxymethylbilane synthase
IPR022418Porphobilinogen deaminase, C-terminal
IPR022417Porphobilinogen deaminase, N-terminal

Mapman id Description
19.5tetrapyrrole synthesis.porphobilinogen deaminase
No SignalP domains detected for this gene.