Gene: AT5G06460 (Arabidopsis thaliana)

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Gene Identifier
AT5G06460
Transcript Identifier
AT5G06460.1
Gene Type
Coding gene
Location
5 : 1970239-1974382 : positive

Family

Gene family
HOM03M001356
(55 genes in 16 species)
specific family
Subfamily
ORTHO03M000297
(17 genes in 13 species)
specific family

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Descriptions

Description
ubiquitin activating enzyme 2
Curated Summary
Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined.
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Identifiers

Identifier Name
aliasATUBA2
aliasARABIDOPSIS THALIANA UBIQUITIN ACTIVATING ENZYME 2
aliasUBA 2
aliasubiquitin activating enzyme 2
uniprotP92974

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006511TASGene Ontologyubiquitin-dependent protein catabolic process1
GO:0000741RCAGene Ontologykaryogamy1
GO:0006310RCAGene OntologyDNA recombination1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0007126RCAGene Ontologymeiosis1
GO:0009560RCAGene Ontologyembryo sac egg cell differentiation1
GO:0009640RCAGene Ontologyphotomorphogenesis1
GO:0010332RCAGene Ontologyresponse to gamma radiation1
GO:0010388RCAGene Ontologycullin deneddylation1
GO:0010564RCAGene Ontologyregulation of cell cycle process1
GO:0016567IDA, RCAGene Ontologyprotein ubiquitination1 2
GO:0016571RCAGene Ontologyhistone methylation1
GO:0016579RCAGene Ontologyprotein deubiquitination1
GO:0032204RCAGene Ontologyregulation of telomere maintenance1
GO:0043247RCAGene Ontologytelomere maintenance in response to DNA damage1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0006464IEAInterProcellular protein modification process
GO:0051707ISOPLAZA Integrative Orthologyresponse to other organismAT2G30110
GO:0046686ISOPLAZA Integrative Orthologyresponse to cadmium ionAT2G30110
GO:0036211IEAPLAZA Homologyprotein modification processHOM03M001356

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004839IMP, ISSGene Ontologyubiquitin activating enzyme activity1 2
GO:0004842IDAUniProtubiquitin-protein ligase activity1 2 3 4
GO:0005524IEAUniProtATP binding1 2 3
GO:0008641IEAUniProtsmall protein activating enzyme activity1 2 3
GO:0016881IEAInterProacid-amino acid ligase activity
GO:0003824IEAInterProcatalytic activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005829IDAUniProtcytosol1 2 3 4
GO:0005634TASUniProtnucleus1 2 3 4
GO:0009506ISOPLAZA Integrative OrthologyplasmodesmaAT2G30110
GO:0005886ISOPLAZA Integrative Orthologyplasma membraneAT2G30110

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR016040NAD(P)-binding domain
IPR000594UBA/THIF-type NAD/FAD binding fold
IPR009036Molybdenum cofactor biosynthesis, MoeB
IPR023318Ubiquitin activating enzyme, alpha domain
IPR019572Ubiquitin-activating enzyme
IPR000011Ubiquitin/SUMO-activating enzyme E1
IPR018965Ubiquitin-activating enzyme e1, C-terminal
IPR018074Ubiquitin-activating enzyme, E1, active site
IPR018075Ubiquitin-activating enzyme, E1
IPR000127Ubiquitin-activating enzyme repeat

Mapman id Description
29.5.11.2protein.degradation.ubiquitin.E1
No SignalP domains detected for this gene.