Gene: AT5G04560 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G04560
Transcript Identifier
AT5G04560.2
Gene Type
Coding gene
Location
5 : 1309786-1318091 : positive

Family

Gene family
HOM03M001003
(72 genes in 16 species)
specific family

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Descriptions

Description
HhH-GPD base excision DNA repair family protein
Curated Summary
Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele.
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Identifiers

Identifier Name
aliasDME
aliasDEMETER
uniprotQ8LK56

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009793IMPUniProtembryo development ending in seed dormancy1 2 3 4 5 6 7
GO:0006349IMPUniProtregulation of gene expression by genetic imprinting1 2 3 4 5 6 7
GO:0006306IDA, RCA, UniProtDNA methylation1 2 3 4 5 6 7 8
GO:0006284IEAUniProtbase-excision repair1 2 3 4 5 6
GO:0006355IEAUniProtregulation of transcription, DNA-dependent1 2 3 4 5 6
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6
GO:0006281IEAInterProDNA repair

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0019104IDA, ISS, UniProtDNA N-glycosylase activity1 2 3 4 5 6 7 8
GO:0003906IDAUniProtDNA-(apurinic or apyrimidinic site) lyase activity1 2 3 4 5 6 7
GO:0051539IEAUniProt4 iron, 4 sulfur cluster binding1 2 3 4 5 6
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6
GO:0003824IEAInterProcatalytic activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISM, ISSGene Ontologynucleus1 2
GO:0043078IDAUniProtpolar nucleus1 2 3 4 5 6 7

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR023170Helix-turn-helix, base-excision DNA repair, C-terminal
IPR003651Endonuclease III-like, iron-sulphur cluster loop motif
IPR011257DNA glycosylase
IPR003265HhH-GPD domain

Mapman id Description
27.3.34RNA.regulation of transcription.Orphan family
No SignalP domains detected for this gene.