Gene: AT4G39400 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT4G39400
Transcript Identifier
AT4G39400.1
Gene Type
Coding gene
Location
4 : 18324826-18328416 : positive

Family

Gene family
HOM03M000005
(2350 genes in 16 species)
specific family
Duplication type
Block duplicate

Loading...please wait

Descriptions

Description
Leucine-rich receptor-like protein kinase family protein
Curated Summary
Encodes a plasma membrane localized leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. BRI1 ligand is brassinolide which binds at the extracellular domain. Binding results in phosphorylation of the kinase domain which activates the BRI1 protein leading to BR responses. Residue T-1049 and either S-1044 or T-1045 were essential for kinase function in vitro and normal BRI1 signaling in planta. The structure of BRI1 ligand-binding domain has been determined at 2.5A resolution. Although BAK1 and BRI1 alone localize in the plasma membrane, when BAK1 and BRI1 are coexpressed, the heterodimer BAK1/BRI1 they form is localized in the endosome. BRI1 appears to be involved in the autonomous pathway that regulates the transition to flowering, primarily through its effects on FLC expression levels, as uncovered by double mutant analyses. This most likely occurs as a result of BRI1-dependent effects on histone acetylation, but not histone triMeH3K4 methylation, at the FLC locus.
Show more...

Identifiers

Identifier Name
aliasBIN1
aliasATBRI1
aliasBR INSENSITIVE 1
aliasDWARF 2
aliasBRASSINOSTEROID INSENSITIVE 1
aliasCBB2
aliasBRI1
aliasDWF2
aliasCABBAGE 2
uniprotO22476

Toolbox

Explore

View

 

Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009826IMPGene Ontologyunidimensional cell growth1
GO:0010224IGIUniProtresponse to UV-B1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0010268IEPUniProtbrassinosteroid homeostasis1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0060548IMPUniProtnegative regulation of cell death1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:1900140IMPUniProtregulation of seedling development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0009911IGIUniProtpositive regulation of flower development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0009742IMP, IEPUniProtbrassinosteroid mediated signaling pathway1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
GO:0010584IMPUniProtpollen exine formation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0048657IMPUniProtanther wall tapetum cell differentiation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0048366IMPUniProtleaf development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0000271RCAGene Ontologypolysaccharide biosynthetic process1
GO:0002237RCAGene Ontologyresponse to molecule of bacterial origin1
GO:0007165RCAGene Ontologysignal transduction1
GO:0009825RCAGene Ontologymultidimensional cell growth1
GO:0009932RCAGene Ontologycell tip growth1
GO:0010103RCAGene Ontologystomatal complex morphogenesis1
GO:0010817RCAGene Ontologyregulation of hormone levels1
GO:0016310RCAGene Ontologyphosphorylation1
GO:0042742RCAGene Ontologydefense response to bacterium1
GO:0043481RCAGene Ontologyanthocyanin accumulation in tissues in response to UV light1
GO:0048443RCAGene Ontologystamen development1
GO:0048767RCAGene Ontologyroot hair elongation1
GO:0071555RCAGene Ontologycell wall organization1
GO:0009729IMPUniProtdetection of brassinosteroid stimulus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0018108IEAUniProtpeptidyl-tyrosine phosphorylation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
GO:0006468IEAInterProprotein phosphorylation
GO:0044260IEAPLAZA Homologycellular macromolecule metabolic processHOM03M000005
GO:0006796IEAPLAZA Homologyphosphate-containing compound metabolic processHOM03M000005
GO:0006793IEAPLAZA Homologyphosphorus metabolic processHOM03M000005
GO:0043170IEAPLAZA Homologymacromolecule metabolic processHOM03M000005
GO:0044237IEAPLAZA Homologycellular metabolic processHOM03M000005
GO:0044238IEAPLAZA Homologyprimary metabolic processHOM03M000005
GO:0009987IEAPLAZA Homologycellular processHOM03M000005
GO:0008152IEAPLAZA Homologymetabolic processHOM03M000005
GO:0043412IEAPLAZA Homologymacromolecule modificationHOM03M000005
GO:0071704IEAPLAZA Homologyorganic substance metabolic processHOM03M000005
GO:0044267IEAPLAZA Homologycellular protein metabolic processHOM03M000005
GO:0006464IEAPLAZA Homologycellular protein modification processHOM03M000005
GO:0036211IEAPLAZA Homologyprotein modification processHOM03M000005
GO:0019538IEAPLAZA Homologyprotein metabolic processHOM03M000005

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016301ISSGene Ontologykinase activity1
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0042802IPIGene Ontologyidentical protein binding1
GO:0046982IPIGene Ontologyprotein heterodimerization activity1
GO:0042803IDAUniProtprotein homodimerization activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0004674IDA, IEA, UniProtprotein serine/threonine kinase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0004672IDA, IEAGene Ontologyprotein kinase activity1
GO:0005496IDAUniProtsteroid binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
GO:0004714IEAUniProttransmembrane receptor protein tyrosine kinase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
GO:0016772IEAInterProtransferase activity, transferring phosphorus-containing groups
GO:0032555IEAPLAZA Homologypurine ribonucleotide bindingHOM03M000005
GO:0043168IEAPLAZA Homologyanion bindingHOM03M000005
GO:0032553IEAPLAZA Homologyribonucleotide bindingHOM03M000005
GO:0043167IEAPLAZA Homologyion bindingHOM03M000005
GO:0035639IEAPLAZA Homologypurine ribonucleoside triphosphate bindingHOM03M000005
GO:0097367IEAPLAZA Homologycarbohydrate derivative bindingHOM03M000005
GO:0003824IEAPLAZA Homologycatalytic activityHOM03M000005
GO:0032559IEAPLAZA Homologyadenyl ribonucleotide bindingHOM03M000005
GO:1901265IEAPLAZA Homologynucleoside phosphate bindingHOM03M000005
GO:0000166IEAPLAZA Homologynucleotide bindingHOM03M000005
GO:0001882IEAPLAZA Homologynucleoside bindingHOM03M000005
GO:0030554IEAPLAZA Homologyadenyl nucleotide bindingHOM03M000005
GO:0016773IEAPLAZA Homologyphosphotransferase activity, alcohol group as acceptorHOM03M000005
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03M000005
GO:0017076IEAPLAZA Homologypurine nucleotide bindingHOM03M000005
GO:0036094IEAPLAZA Homologysmall molecule bindingHOM03M000005
GO:0032549IEAPLAZA Homologyribonucleoside bindingHOM03M000005
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03M000005
GO:0005488IEAPLAZA HomologybindingHOM03M000005
GO:0001883IEAPLAZA Homologypurine nucleoside bindingHOM03M000005
GO:0016740IEAPLAZA Homologytransferase activityHOM03M000005
GO:0032550IEAPLAZA Homologypurine ribonucleoside bindingHOM03M000005

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005886IDA, ISM, UniProtplasma membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
GO:0005768IDAUniProtendosome1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0043234IPIUniProtprotein complex1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0010008IEAUniProtendosome membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003591Leucine-rich repeat, typical subtype
IPR001611Leucine-rich repeat
IPR000719Protein kinase domain
IPR013210Leucine-rich repeat-containing N-terminal, type 2
IPR017441Protein kinase, ATP binding site
IPR013320Concanavalin A-like lectin/glucanase, subgroup
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR002290Serine/threonine- / dual specificity protein kinase, catalytic domain

Mapman id Description
17.3.2.1hormone metabolism.brassinosteroid.signal transduction.BRI
SignalP Description
SignalP-noTMSignal Peptide detected using noTM network