Gene: AT4G30870 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT4G30870
Transcript Identifier
AT4G30870.1
Gene Type
Coding gene
Location
4 : 15028586-15032461 : positive

Family

Gene family
HOM03M003508
(25 genes in 16 species)
specific family
Subfamily
ORTHO03M024437
(2 genes in 2 species)
specific family

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Descriptions

Description
Restriction endonuclease, type II-like superfamily protein
Curated Summary
Encodes an Arabidopsis homolog of the endonuclease MSU81. T-DNA insertion lines of AtMSU81 have a deficiency in homologous recombination in somatic cells but only after genotoxic stress. Crosses with a hyperrecombinogenic mutant of the AtRecQ4A helicase resulted in synthetic lethality in the double mutant.
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Identifiers

Identifier Name
aliasARABIDOPSIS THALIANA MMS AND UV SENSITIVE 81
aliasMMS AND UV SENSITIVE 81
aliasATMUS81
aliasMUS81
uniprotQ5W9E7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006281IMP, ISSGene OntologyDNA repair1 2
GO:0006312IMP, RCA, UniProtmitotic recombination1 2 3 4 5 6 7 8 9 10
GO:0006974IEPGene Ontologycellular response to DNA damage stimulus1
GO:0051026IGIUniProtchiasma assembly1 2 3 4 5 6 7 8 9
GO:0000724IMP, RCA, UniProtdouble-strand break repair via homologous recombination1 2 3 4 5 6 7 8 9 10
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0006302RCAGene Ontologydouble-strand break repair1
GO:0006355RCAGene Ontologyregulation of transcription, DNA-dependent1
GO:0006396RCAGene OntologyRNA processing1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007129RCAGene Ontologysynapsis1
GO:0007131RCAGene Ontologyreciprocal meiotic recombination1
GO:0007140RCAGene Ontologymale meiosis1
GO:0008284RCAGene Ontologypositive regulation of cell proliferation1
GO:0009410RCAGene Ontologyresponse to xenobiotic stimulus1
GO:0009560RCAGene Ontologyembryo sac egg cell differentiation1
GO:0016444RCAGene Ontologysomatic cell DNA recombination1
GO:0042138RCAGene Ontologymeiotic DNA double-strand break formation1
GO:0043687RCAGene Ontologypost-translational protein modification1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1
GO:0048522RCAGene Ontologypositive regulation of cellular process1
GO:0051276RCAGene Ontologychromosome organization1
GO:0051301IEAUniProtcell division1 2 3 4 5 6 7 8
GO:0007067IEAUniProtmitosis1 2 3 4 5 6 7 8
GO:0006259IEAInterProDNA metabolic process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003676ISSGene Ontologynucleic acid binding1
GO:0004519IEA, ISSUniProtendonuclease activity1 2 3 4 5 6 7 8 9
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6 7 8
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6 7 8
GO:0004518IEAInterPronuclease activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0000794IDAUniProtcondensed nuclear chromosome1 2 3 4 5 6 7 8 9
GO:0005730IEAUniProtnucleolus1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011335Restriction endonuclease type II-like
IPR006166ERCC4 domain
IPR020819DNA repair nuclease, XPF-type/Helicase

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.