Gene: AT4G26970 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
4 : 13543077-13548427 : positive


Gene family
(54 genes in 15 species)
specific family
Duplication type
Block duplicate

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aconitase 2
Curated Summary
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro.
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Identifier Name
aliasaconitase 2





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0046686IEP, RCA, UniProtresponse to cadmium ion1 2 3 4 5
GO:0006101IMPUniProtcitrate metabolic process1 2 3 4
GO:0006102IMPUniProtisocitrate metabolic process1 2 3 4
GO:0006979IMPUniProtresponse to oxidative stress1 2 3 4
GO:0006094RCAGene Ontologygluconeogenesis1
GO:0006096RCAGene Ontologyglycolysis1
GO:0006487RCAGene Ontologyprotein N-linked glycosylation1
GO:0007010RCAGene Ontologycytoskeleton organization1
GO:0009060RCAGene Ontologyaerobic respiration1
GO:0010167RCAGene Ontologyresponse to nitrate1
GO:0010498RCAGene Ontologyproteasomal protein catabolic process1
GO:0015706RCAGene Ontologynitrate transport1
GO:0006097IEAUniProtglyoxylate cycle1 2 3
GO:0006099IEAUniProttricarboxylic acid cycle1 2 3
GO:0008152IEAInterPrometabolic process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003994IMP, ISS, UniProtaconitate hydratase activity1 2 3 4 5
GO:0005507IDAUniProtcopper ion binding1 2 3 4
GO:0051539IEAUniProt4 iron, 4 sulfur cluster binding1 2 3

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005739IDA, ISM, UniProtmitochondrion1 2 3 4 5
GO:0005829NASUniProtcytosol1 2 3 4
GO:0009507IDAUniProtchloroplast1 2 3 4

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001030Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR018136Aconitase family, 4Fe-4S cluster binding site
IPR015931Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
IPR015934Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase
IPR015937Aconitase/isopropylmalate dehydratase
IPR015928Aconitase/3-isopropylmalate dehydratase, swivel
IPR000573Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR015932Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
IPR006249Aconitase/iron regulatory protein 2

Mapman id Description
8.1.3TCA / org transformation.TCA.aconitase
No SignalP domains detected for this gene.