Gene: AT4G20260 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT4G20260
Transcript Identifier
AT4G20260.4
Gene Type
Coding gene
Location
4 : 10941593-10943227 : positive

Family

Gene family
HOM03M003860
(24 genes in 13 species)
specific family

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Descriptions

Description
plasma-membrane associated cation-binding protein 1
Curated Summary
Encodes a Ca2+ and Cu2+ binding protein. N-terminal myristylation on glycine 2 appears to enable it to associate tightly with the plasma membrane. Recombinant PCaP1 interacts strongly with phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and PtdIns (3,4,5)P3, and weakly with PtdIns(3,5)P2 and PtdIns(4,5). It also interacts with calmodulin (CaM) in a calcium-dependent manner. CaM does not interfere with PCaP1 membrane localization but does weaken interactions between it and the PtdInsPs. PCaP1 has an apparent Kd of 10 uM for Cu2+ and can bind six ions per protein. Transcript levels for PCaP1 first fall and then rise following exposure to CuCl2. Mannitol, sorbitol, and the flg22 oligopeptide also increase expression levels.
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Identifiers

Identifier Name
aliasplasma-membrane associated cation-binding protein 1
aliasmicrotubule-destabilizing protein 25
aliasATPCAP1
aliasARABIDOPSIS THALIANA PLASMA-MEMBRANE ASSOCIATED CATION-BINDING PROTEIN 1
aliasPCAP1
aliasMDP25
uniprotQ96262

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009409IEPGene Ontologyresponse to cold1
GO:0042742IEPGene Ontologydefense response to bacterium1
GO:0009414IEPUniProtresponse to water deprivation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0010350IEPUniProtcellular response to magnesium starvation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0035865IEPUniProtcellular response to potassium ion1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071219IEPUniProtcellular response to molecule of bacterial origin1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071280IEPUniProtcellular response to copper ion1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071281IEPUniProtcellular response to iron ion1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071286IEPUniProtcellular response to magnesium ion1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071325IEPUniProtcellular response to mannitol stimulus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0071472IEPUniProtcellular response to salt stress1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0072709IEPUniProtcellular response to sorbitol1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0006499IMPUniProtN-terminal protein myristoylation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0031115IDAGene Ontologynegative regulation of microtubule polymerization1
GO:0031117IDAUniProtpositive regulation of microtubule depolymerization1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0043622IDA, IMP, UniProtcortical microtubule organization1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0051511IMPUniProtnegative regulation of unidimensional cell growth1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0051592IDAGene Ontologyresponse to calcium ion1
GO:0075733IMPGene Ontologyintracellular transport of virus1
GO:0006816RCAGene Ontologycalcium ion transport1
GO:0006970RCAGene Ontologyresponse to osmotic stress1
GO:0007030RCAGene OntologyGolgi organization1
GO:0009651RCAGene Ontologyresponse to salt stress1
GO:0046686RCAGene Ontologyresponse to cadmium ion1
GO:0048767RCAGene Ontologyroot hair elongation1
GO:0019048IEAUniProtmodulation by virus of host morphology or physiology1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0051716IEAInterProcellular response to stimulus

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005509IDAUniProtcalcium ion binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005516IDAUniProtcalmodulin binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005546IDAUniProtphosphatidylinositol-4,5-bisphosphate binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005547IDAUniProtphosphatidylinositol-3,4,5-trisphosphate binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0043325IDAUniProtphosphatidylinositol-3,4-bisphosphate binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0080025IDAUniProtphosphatidylinositol-3,5-bisphosphate binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005507IDAUniProtcopper ion binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0008017IDAUniProtmicrotubule binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005515IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005886IDA, ISSGene Ontologyplasma membrane1 2
GO:0009507IDAGene Ontologychloroplast1
GO:0005773IDAGene Ontologyvacuole1
GO:0046658IDA, IEA, UniProtanchored to plasma membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0005881IDAUniProtcytoplasmic microtubule1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0009506IDAUniProtplasmodesma1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008469DREPP family

Mapman id Description
30.4signalling.phosphinositides
No SignalP domains detected for this gene.