Gene: AT3G54610 (Arabidopsis thaliana)

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Gene Identifier
AT3G54610
Transcript Identifier
AT3G54610.1
Gene Type
Coding gene
Location
3 : 20213593-20217375 : positive

Family

Gene family
HOM03M005475
(18 genes in 15 species)
specific family

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Descriptions

Description
histone acetyltransferase of the GNAT family 1
Curated Summary
Encodes a histone acetyltransferase that is plays a role in the determination of the embryonic root-shoot axis. It is also required to regulate the floral meristem activity by modulating the extent of expression of WUS and AG. In other eukaryotes, this protein is recruited to specific promoters by DNA binding transcription factors and is thought to promote transcription by acetylating the N-terminal tail of histone H3. The enzyme has indeed been shown to catalyse primarily the acetylation of H3 histone with only traces of H4 and H2A/B being acetylated. Non-acetylated H3 peptide or an H3 peptide that had been previously acetylated on K9 both serve as excellent substrates for HAG1-catalyzed acetylation. However, prior acetylation of H3 lysine 14 blocks radioactive acetylation of the peptide by HAG1. HAG1 is specific for histone H3 lysine 14.
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Identifiers

Identifier Name
aliashistone acetyltransferase of the GNAT family 1
aliasHAT1
aliasHISTONE ACETYLTRANSFERASE 1
aliasGCN5
aliasHAG1
aliasHAC3
aliasBIG TOP
aliasHAG01
aliasBGT
aliasgeneral control non-repressible 5
uniprotQ9AR19

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0045893TAS, RCAUniProtpositive regulation of transcription, DNA-dependent1 2 3 4 5 6 7 8 9 10 11
GO:0009908IMPUniProtflower development1 2 3 4 5 6 7 8 9 10
GO:0009416IMPUniProtresponse to light stimulus1 2 3 4 5 6 7 8 9 10
GO:0010015IMPUniProtroot morphogenesis1 2 3 4 5 6 7 8 9 10
GO:0016573IDAGene Ontologyhistone acetylation1
GO:0006355RCAGene Ontologyregulation of transcription, DNA-dependent1
GO:0009410RCAGene Ontologyresponse to xenobiotic stimulus1
GO:0009640RCAGene Ontologyphotomorphogenesis1
GO:0010388RCAGene Ontologycullin deneddylation1
GO:0016567RCAGene Ontologyprotein ubiquitination1
GO:0016571RCAGene Ontologyhistone methylation1
GO:0016579RCAGene Ontologyprotein deubiquitination1
GO:0043687RCAGene Ontologypost-translational protein modification1
GO:0048522RCAGene Ontologypositive regulation of cellular process1
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004402IDA, ISSGene Ontologyhistone acetyltransferase activity1 2
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0003677IDAUniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0010484IDAUniProtH3 histone acetyltransferase activity1 2 3 4 5 6 7 8 9 10
GO:0008080IEAInterProN-acetyltransferase activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISMGene Ontologynucleus1 2
GO:0000123IPIUniProthistone acetyltransferase complex1 2 3 4 5 6 7 8 9 10

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000182GNAT domain
IPR016181Acyl-CoA N-acyltransferase
IPR001487Bromodomain
IPR018359Bromodomain, conserved site

Mapman id Description
27.3.54RNA.regulation of transcription.Histone acetyltransferases
No SignalP domains detected for this gene.
DatabaseType
PlnTFDBGNAT