Gene: AT3G51840 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 19225653-19229008 : negative


Gene family
(37 genes in 15 species)
specific family

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acyl-CoA oxidase 4
Curated Summary
Encodes a short-chain acyl-CoA oxidase, which catalyzes the first step of peroxisomal fatty acid beta-oxidation during early, post-germinative growth in oilseed species. Null mutants virtually lack short-chain acyl-CoA and are resistant to 2,4-dichlorophenoxybutyric acid, which is converted to the herbicide and auxin analogue 2,4-dichlorophenoxyacetic acid by beta-oxidation. Despite the almost complete loss of short-chain activity, lipid catabolism and seedling growth and establishment was unaltered in the acx4 mutant. However, double mutants in acx3acx4 (acx3 encodes medium chain acyl CoA oxidase) were not viable and arrested during embryogenesis.
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Identifier Name
aliasacyl-CoA oxidase 4





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006635IDA, IMPRCA, UniProtfatty acid beta-oxidation1 2 3 4 5 6 7 8
GO:0009793IGIUniProtembryo development ending in seed dormancy1 2 3 4 5 6
GO:0046459TASUniProtshort-chain fatty acid metabolic process1 2 3 4 5 6
GO:0006623RCAGene Ontologyprotein targeting to vacuole1
GO:0007030RCAGene OntologyGolgi organization1
GO:0007033RCAGene Ontologyvacuole organization1
GO:0016192RCAGene Ontologyvesicle-mediated transport1
GO:0016558RCAGene Ontologyprotein import into peroxisome matrix1
GO:0044265RCAGene Ontologycellular macromolecule catabolic process1
GO:0008152IEAInterPrometabolic process
GO:0055114IEAInterProoxidation-reduction process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016491ISSGene Ontologyoxidoreductase activity1
GO:0003997IDA, IMP, UniProtacyl-CoA oxidase activity1 2 3 4 5 6 7
GO:0003995IEAUniProtacyl-CoA dehydrogenase activity1 2 3 4 5
GO:0050660IEAUniProtflavin adenine dinucleotide binding1 2 3 4 5
GO:0016627IEAInterProoxidoreductase activity, acting on the CH-CH group of donors

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005739ISMGene Ontologymitochondrion1
GO:0005777IDAUniProtperoxisome1 2 3 4 5 6
GO:0005829RCAGene Ontologycytosol1
GO:0009514IEAUniProtglyoxysome1 2 3 4 5

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR009075Acyl-CoA dehydrogenase/oxidase C-terminal
IPR006091Acyl-CoA oxidase/dehydrogenase, central domain
IPR009100Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR013786Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR006089Acyl-CoA dehydrogenase, conserved site

Mapman id Description metabolism.lipid degradation.beta-oxidation.acyl CoA DH
No SignalP domains detected for this gene.