Gene: AT3G48750 (Arabidopsis thaliana)

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Gene Identifier
AT3G48750
Transcript Identifier
AT3G48750.1
Gene Type
Coding gene
Location
3 : 18072238-18074296 : positive

Family

Gene family
HOM03M000026
(1147 genes in 16 species)
specific family
Subfamily
ORTHO03M003915
(7 genes in 5 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
cell division control 2
Curated Summary
A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.
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Identifiers

Identifier Name
aliasCDKA1
aliascell division control 2
aliasCDK2
aliasCDC2AAT
aliasCDKA;1
aliasCDC2
aliasCDC2A
uniprotP24100

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0042023IMP, RCA, UniProtDNA endoreduplication1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
GO:0009555IMPUniProtpollen development1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0008284IMPUniProtpositive regulation of cell proliferation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0009793IMPUniProtembryo development ending in seed dormancy1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0040020IMPUniProtregulation of meiosis1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0048229IMPGene Ontologygametophyte development1
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0006995RCAGene Ontologycellular response to nitrogen starvation1
GO:0010048RCAGene Ontologyvernalization response1
GO:0010440RCAGene Ontologystomatal lineage progression1
GO:0045736RCAGene Ontologynegative regulation of cyclin-dependent protein serine/threonine kinase activity1
GO:0008356IGIUniProtasymmetric cell division1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0000910IMPGene Ontologycytokinesis1
GO:0009409IEPUniProtresponse to cold1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0007067IEAUniProtmitosis1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
GO:0006468IEAInterProprotein phosphorylation
GO:0044260IEAPLAZA Homologycellular macromolecule metabolic processHOM03M000026
GO:0006796IEAPLAZA Homologyphosphate-containing compound metabolic processHOM03M000026
GO:0006793IEAPLAZA Homologyphosphorus metabolic processHOM03M000026
GO:0043170IEAPLAZA Homologymacromolecule metabolic processHOM03M000026
GO:0044237IEAPLAZA Homologycellular metabolic processHOM03M000026
GO:0044238IEAPLAZA Homologyprimary metabolic processHOM03M000026
GO:0009987IEAPLAZA Homologycellular processHOM03M000026
GO:0016310IEAPLAZA HomologyphosphorylationHOM03M000026
GO:0008152IEAPLAZA Homologymetabolic processHOM03M000026
GO:0043412IEAPLAZA Homologymacromolecule modificationHOM03M000026
GO:0071704IEAPLAZA Homologyorganic substance metabolic processHOM03M000026
GO:0044267IEAPLAZA Homologycellular protein metabolic processHOM03M000026
GO:0006464IEAPLAZA Homologycellular protein modification processHOM03M000026
GO:0036211IEAPLAZA Homologyprotein modification processHOM03M000026
GO:0019538IEAPLAZA Homologyprotein metabolic processHOM03M000026

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016301IMP, ISSGene Ontologykinase activity1 2
GO:0005515IPIGene Ontologyprotein binding1
GO:0004672IDA, IEAGene Ontologyprotein kinase activity1
GO:0004693ISSUniProtcyclin-dependent protein serine/threonine kinase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
GO:0008353IEAUniProtRNA polymerase II carboxy-terminal domain kinase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
GO:0004674IEAInterProprotein serine/threonine kinase activity
GO:0016772IEAInterProtransferase activity, transferring phosphorus-containing groups
GO:0032555IEAPLAZA Homologypurine ribonucleotide bindingHOM03M000026
GO:0043168IEAPLAZA Homologyanion bindingHOM03M000026
GO:0032553IEAPLAZA Homologyribonucleotide bindingHOM03M000026
GO:0043167IEAPLAZA Homologyion bindingHOM03M000026
GO:0035639IEAPLAZA Homologypurine ribonucleoside triphosphate bindingHOM03M000026
GO:0097367IEAPLAZA Homologycarbohydrate derivative bindingHOM03M000026
GO:0003824IEAPLAZA Homologycatalytic activityHOM03M000026
GO:0032559IEAPLAZA Homologyadenyl ribonucleotide bindingHOM03M000026
GO:1901265IEAPLAZA Homologynucleoside phosphate bindingHOM03M000026
GO:0000166IEAPLAZA Homologynucleotide bindingHOM03M000026
GO:0001882IEAPLAZA Homologynucleoside bindingHOM03M000026
GO:0030554IEAPLAZA Homologyadenyl nucleotide bindingHOM03M000026
GO:0016773IEAPLAZA Homologyphosphotransferase activity, alcohol group as acceptorHOM03M000026
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03M000026
GO:0017076IEAPLAZA Homologypurine nucleotide bindingHOM03M000026
GO:0036094IEAPLAZA Homologysmall molecule bindingHOM03M000026
GO:0032549IEAPLAZA Homologyribonucleoside bindingHOM03M000026
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03M000026
GO:0005488IEAPLAZA HomologybindingHOM03M000026
GO:0001883IEAPLAZA Homologypurine nucleoside bindingHOM03M000026
GO:0016740IEAPLAZA Homologytransferase activityHOM03M000026
GO:0032550IEAPLAZA Homologypurine ribonucleoside bindingHOM03M000026

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
GO:0005886IDAUniProtplasma membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0005829IDAUniProtcytosol1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0005737IDAGene Ontologycytoplasm1
GO:0009574TASUniProtpreprophase band1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
GO:0010005IDAUniProtcortical microtubule, transverse to long axis1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR017441Protein kinase, ATP binding site
IPR011009Protein kinase-like domain
IPR000719Protein kinase domain
IPR002290Serine/threonine- / dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site

Mapman id Description
31.3cell.cycle
No SignalP domains detected for this gene.