Gene: AT3G48190 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G48190
Transcript Identifier
AT3G48190.1
Gene Type
Coding gene
Location
3 : 17797628-17828361 : positive

Family

Gene family
HOM03M001441
(53 genes in 16 species)
specific family

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Descriptions

Description
ataxia-telangiectasia mutated
Curated Summary
Encodes a homolog of the human ATM gene, which is mutated in ataxia telangiectasia, a chromosome instability disorder. Characterization of mutants suggest a role in repairing DNA in response to ionizing radiation as well as during meiosis. The protein has kinase domains and shows kinase activity in orthologs. There is also evidence that ATM might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.
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Identifiers

Identifier Name
aliasataxia-telangiectasia mutated
aliasATM
aliaspcd in male gametogenesis 1
aliasARABIDOPSIS THALIANA ATAXIA-TELANGIECTASIA MUTATED
aliasATATM
aliasPIG1
uniprotQ9M3G7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006281IEA, IMPUniProtDNA repair1 2 3 4 5 6
GO:0007126IEA, IMP, RCAUniProtmeiosis1 2 3 4 5 6 7
GO:0007131IMP, RCAGene Ontologyreciprocal meiotic recombination1 2
GO:0010212IEA, IMP, RCAUniProtresponse to ionizing radiation1 2 3 4 5 6 7
GO:0032504IGI, RCAGene Ontologymulticellular organism reproduction1 2
GO:0043247RCA, TASGene Ontologytelomere maintenance in response to DNA damage1 2
GO:0010332IMP, RCAGene Ontologyresponse to gamma radiation1 2
GO:0032204IGI, RCAGene Ontologyregulation of telomere maintenance1 2
GO:0033044IGI, RCAGene Ontologyregulation of chromosome organization1 2
GO:0000003RCAGene Ontologyreproduction1
GO:0000724RCAGene Ontologydouble-strand break repair via homologous recombination1
GO:0006259RCAGene OntologyDNA metabolic process1
GO:0006310RCAGene OntologyDNA recombination1
GO:0006325RCAGene Ontologychromatin organization1
GO:0006355RCAGene Ontologyregulation of transcription, DNA-dependent1
GO:0007059RCAGene Ontologychromosome segregation1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007129RCAGene Ontologysynapsis1
GO:0009887RCAGene Ontologyorgan morphogenesis1
GO:0009888RCAGene Ontologytissue development1
GO:0010090RCAGene Ontologytrichome morphogenesis1
GO:0010638RCAGene Ontologypositive regulation of organelle organization1
GO:0042138RCAGene Ontologymeiotic DNA double-strand break formation1
GO:0043687RCAGene Ontologypost-translational protein modification1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1
GO:0000077IEAUniProtDNA damage checkpoint1 2 3 4 5
GO:0016572IEAUniProthistone phosphorylation1 2 3 4 5
GO:0090399IEAUniProtreplicative senescence1 2 3 4 5
GO:0000723IEAUniProttelomere maintenance1 2 3 4 5
GO:0006974IEAInterProcellular response to DNA damage stimulus

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000285TASGene Ontology1-phosphatidylinositol-3-phosphate 5-kinase activity1
GO:0005524IEAUniProtATP binding1 2 3 4 5
GO:0003677IEAUniProtDNA binding1 2 3 4 5
GO:0004674IEAUniProtprotein serine/threonine kinase activity1 2 3 4 5
GO:0005515IEAInterProprotein binding
GO:0005488IEAInterProbinding
GO:0016773IEAInterProphosphotransferase activity, alcohol group as acceptor
GO:0016772IEAInterProtransferase activity, transferring phosphorus-containing groups

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5 6
GO:0009507IDAGene Ontologychloroplast1
GO:0009506IDAGene Ontologyplasmodesma1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR016024Armadillo-type fold
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR011009Protein kinase-like domain
IPR018936Phosphatidylinositol 3/4-kinase, conserved site
IPR015519ATM/Tel1
IPR000313PWWP domain
IPR014009PIK-related kinase
IPR003152PIK-related kinase, FATC
IPR003151PIK-related kinase, FAT

Mapman id Description
29.4.1protein.postranslational modification.kinase
No SignalP domains detected for this gene.