Gene: AT3G25070 (Arabidopsis thaliana)

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Gene Identifier
AT3G25070
Transcript Identifier
AT3G25070.1
Gene Type
Coding gene
Location
3 : 9132458-9133747 : positive

Family

Gene family
HOM03M001661
(47 genes in 13 species)
specific family
Subfamily
ORTHO03M011430
(4 genes in 4 species)
specific family

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Descriptions

Description
RPM1 interacting protein 4
Curated Summary
Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation. Major virulence target of the TTSE HopF2Pto.
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Identifiers

Identifier Name
aliasRIN4
aliasRPM1 interacting protein 4
uniprotQ8GYN5

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009816IMPUniProtdefense response to bacterium, incompatible interaction1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0006468IDAUniProtprotein phosphorylation1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0009626IMPUniProtplant-type hypersensitive response1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0002237IMP, RCA, UniProtresponse to molecule of bacterial origin1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
GO:0010204IMPUniProtdefense response signaling pathway, resistance gene-independent1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0034051IMPUniProtnegative regulation of plant-type hypersensitive response1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0009617RCAGene Ontologyresponse to bacterium1
GO:0045087RCAGene Ontologyinnate immune response1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0016020IDAGene Ontologymembrane1
GO:0005886IDA, TASGene Ontologyplasma membrane1 2
GO:0019897IDAUniProtextrinsic to plasma membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0012505IEAUniProtendomembrane system1 2 3 4 5 6 7 8 9 10 11 12 13

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008700Pathogenic type III effector avirulence factor Avr cleavage site

Mapman id Description
20.1stress.biotic
No SignalP domains detected for this gene.