Gene: AT3G24495 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G24495
Transcript Identifier
AT3G24495.1
Gene Type
Coding gene
Location
3 : 8912418-8918086 : negative

Family

Gene family
HOM03M002099
(39 genes in 16 species)
specific family

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Descriptions

Description
MUTS homolog 7
Curated Summary
encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH7 exhibit moderate affinity for a (T/G) substrate and weak binding of (+T), suggesting MSH2*MSH7 may be specialized for lesions/base mispairs not tested or for (T/G) mispairs in special contexts.
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Identifiers

Identifier Name
aliasMUTS homolog 7
aliasARABIDOPSIS THALIANA MUTS HOMOLOG 7
aliasATMSH7
aliasMSH7
aliasMUTS HOMOLOG 6-2
aliasMSH6-2
uniprotQ9SMV7

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000710IBAUniProtmeiotic mismatch repair1 2 3 4 5 6
GO:0006200IBAGene OntologyATP catabolic process1
GO:0006298ISS, IEAGene Ontologymismatch repair1
GO:0007131IBA, RCA, UniProtreciprocal meiotic recombination1 2 3 4 5 6 7
GO:0009411IBAUniProtresponse to UV1 2 3 4 5 6
GO:0043570IBAUniProtmaintenance of DNA repeat elements1 2 3 4 5 6
GO:0045910IBAUniProtnegative regulation of DNA recombination1 2 3 4 5 6
GO:0000911RCAGene Ontologycytokinesis by cell plate formation1
GO:0006260RCAGene OntologyDNA replication1
GO:0006270RCAGene OntologyDNA replication initiation1
GO:0006275RCAGene Ontologyregulation of DNA replication1
GO:0006306RCAGene OntologyDNA methylation1
GO:0007067RCAGene Ontologymitosis1
GO:0007126RCAGene Ontologymeiosis1
GO:0007129RCAGene Ontologysynapsis1
GO:0008283RCAGene Ontologycell proliferation1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0010389RCAGene Ontologyregulation of G2/M transition of mitotic cell cycle1
GO:0010564RCAGene Ontologyregulation of cell cycle process1
GO:0016458RCAGene Ontologygene silencing1
GO:0034968RCAGene Ontologyhistone lysine methylation1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0051726RCAGene Ontologyregulation of cell cycle1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000400IBAUniProtfour-way junction DNA binding1 2 3 4 5 6
GO:0003684IBA, ISS, UniProtdamaged DNA binding1 2 3 4 5 6 7
GO:0005524IEA, ISSUniProtATP binding1 2 3 4 5 6
GO:0008094IBAUniProtDNA-dependent ATPase activity1 2 3 4 5 6
GO:0032137IBAUniProtguanine/thymine mispair binding1 2 3 4 5 6
GO:0032138IBAUniProtsingle base insertion or deletion binding1 2 3 4 5 6
GO:0005515IPIGene Ontologyprotein binding1
GO:0030983IEAInterPromismatched DNA binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000228IBAUniProtnuclear chromosome1 2 3 4 5 6
GO:0005634ISMGene Ontologynucleus1
GO:0032301IBAUniProtMutSalpha complex1 2 3 4 5 6

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR007860DNA mismatch repair protein MutS, connector domain
IPR015536DNA mismatch repair protein MutS-homologue MSH6
IPR016151DNA mismatch repair protein MutS, N-terminal
IPR007696DNA mismatch repair protein MutS, core
IPR000432DNA mismatch repair protein MutS, C-terminal
IPR007695DNA mismatch repair protein MutS-like, N-terminal

Mapman id Description
28.2DNA.repair
No SignalP domains detected for this gene.