Gene: AT3G23890 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 8624931-8631106 : positive


Gene family
(41 genes in 16 species)
specific family
Duplication type
Block duplicate

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topoisomerase II
Curated Summary
Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.
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Identifier Name
aliastopoisomerase II





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000712IBAUniProtresolution of meiotic recombination intermediates1 2 3 4
GO:0000819IBAUniProtsister chromatid segregation1 2 3 4
GO:0006200IBAGene OntologyATP catabolic process1
GO:0006259ISS, IEAGene OntologyDNA metabolic process1
GO:0006261IBAUniProtDNA-dependent DNA replication1 2 3 4
GO:0006265IBA, ISSIEA, UniProtDNA topological change1 2 3 4 5
GO:0006312IBAUniProtmitotic recombination1 2 3 4
GO:0007059ISSGene Ontologychromosome segregation1
GO:0044774IBAUniProtmitotic DNA integrity checkpoint1 2 3 4
GO:0000226RCAGene Ontologymicrotubule cytoskeleton organization1
GO:0000911RCAGene Ontologycytokinesis by cell plate formation1
GO:0006260RCAGene OntologyDNA replication1
GO:0006270RCAGene OntologyDNA replication initiation1
GO:0006275RCAGene Ontologyregulation of DNA replication1
GO:0006306RCAGene OntologyDNA methylation1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0008283RCAGene Ontologycell proliferation1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0009957RCAGene Ontologyepidermal cell fate specification1
GO:0010583RCAGene Ontologyresponse to cyclopentenone1
GO:0016458RCAGene Ontologygene silencing1
GO:0016572RCAGene Ontologyhistone phosphorylation1
GO:0034968RCAGene Ontologyhistone lysine methylation1
GO:0051225RCAGene Ontologyspindle assembly1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0051726RCAGene Ontologyregulation of cell cycle1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IEA, ISSUniProtDNA binding1 2 3 4
GO:0003918IBA, ISSIEA, UniProtDNA topoisomerase type II (ATP-hydrolyzing) activity1 2 3 4 5
GO:0005524IEA, ISSUniProtATP binding1 2 3 4
GO:0008094IBA, ISSGene OntologyDNA-dependent ATPase activity1 2
GO:0003916ISSGene OntologyDNA topoisomerase activity1
GO:0046872IEAUniProtmetal ion binding1 2 3
GO:0061505IEAPLAZA HomologyDNA topoisomerase II activityHOM03M001998

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000795IBAUniProtsynaptonemal complex1 2 3 4
GO:0005634IDA, ISMGene Ontologynucleus1 2
GO:0009330IBA, ISS, UniProtDNA topoisomerase complex (ATP-hydrolyzing)1 2 3 4 5
GO:0009507ISMGene Ontologychloroplast1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003594Histidine kinase-like ATPase, ATP-binding domain
IPR001241DNA topoisomerase, type IIA
IPR001154DNA topoisomerase II, eukaryotic-type
IPR006171Toprim domain
IPR020568Ribosomal protein S5 domain 2-type fold
IPR013757Type IIA DNA topoisomerase subunit A, alpha-helical domain
IPR018522DNA topoisomerase, type IIA, conserved site
IPR002205DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013759DNA topoisomerase, type IIA, central domain
IPR013760DNA topoisomerase, type IIA-like domain
IPR014721Ribosomal protein S5 domain 2-type fold, subgroup
IPR013506DNA topoisomerase, type IIA, subunit B, domain 2
IPR024946Arginine repressor C-terminal-like domain
IPR013758DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.