Gene: AT3G22590 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G22590
Transcript Identifier
AT3G22590.1
Gene Type
Coding gene
Location
3 : 8003999-8005452 : positive

Family

Gene family
HOM03M005329
(19 genes in 16 species)
specific family

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Descriptions

Description
PLANT HOMOLOGOUS TO PARAFIBROMIN
Curated Summary
Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC).
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Identifiers

Identifier Name
aliasCDC73
aliasPLANT HOMOLOGOUS TO PARAFIBROMIN
aliasPHP

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010228IMPGene Ontologyvegetative to reproductive phase transition of meristem1
GO:0009911IMPGene Ontologypositive regulation of flower development1
GO:0051568IMPGene Ontologyhistone H3-K4 methylation1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISMGene Ontologynucleus1 2
GO:0070860ISSGene OntologyRNA polymerase I core factor complex1
GO:0000120IEAPLAZA HomologyRNA polymerase I transcription factor complexHOM03M005329

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007852RNA polymerase II accessory factor, Cdc73

Mapman id Description
27.2RNA.transcription
No SignalP domains detected for this gene.