Gene: AT3G20475 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 7143546-7150811 : positive


Gene family
(22 genes in 15 species)
specific family

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MUTS-homologue 5
Curated Summary
Encodes MSH5, a homologue of the MutS-homolog family of genes required for normal levels of recombination in budding yeast, mouse and Caenorhabditis elegans. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers. Transcripts of AtMSH5 are specific to reproductive tissues and expression of the protein is abundant during prophase I of meiosis. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers.
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Identifier Name
aliasMUTS-homologue 5





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000710IBAGene Ontologymeiotic mismatch repair1
GO:0006200IBAGene OntologyATP catabolic process1
GO:0006298ISS, IEAGene Ontologymismatch repair1
GO:0045143IMP, IBAUniProthomologous chromosome segregation1 2 3 4 5 6
GO:0007131IMP, RCAGene Ontologyreciprocal meiotic recombination1 2
GO:0051026IMPUniProtchiasma assembly1 2 3 4 5 6
GO:0006302RCAGene Ontologydouble-strand break repair1
GO:0006312RCAGene Ontologymitotic recombination1
GO:0007059RCAGene Ontologychromosome segregation1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007129RCAGene Ontologysynapsis1
GO:0009691RCAGene Ontologycytokinin biosynthetic process1
GO:0010332RCAGene Ontologyresponse to gamma radiation1
GO:0032204RCAGene Ontologyregulation of telomere maintenance1
GO:0032504RCAGene Ontologymulticellular organism reproduction1
GO:0042138RCAGene Ontologymeiotic DNA double-strand break formation1
GO:0043247RCAGene Ontologytelomere maintenance in response to DNA damage1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0010777IDAUniProtmeiotic mismatch repair involved in reciprocal meiotic recombination1 2 3 4 5

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003684IBA, ISS, UniProtdamaged DNA binding1 2 3 4 5 6 7
GO:0005524IEA, ISSUniProtATP binding1 2 3 4 5 6
GO:0008094IBAUniProtDNA-dependent ATPase activity1 2 3 4 5 6
GO:0030983IBA, IEA, UniProtmismatched DNA binding1 2 3 4 5 6

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0000795IBAUniProtsynaptonemal complex1 2 3 4 5 6
GO:0005634ISMGene Ontologynucleus1
GO:0032300IBAUniProtmismatch repair complex1 2 3 4 5 6
GO:0000794IDAGene Ontologycondensed nuclear chromosome1
GO:0043073IDAUniProtgerm cell nucleus1 2 3 4 5

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007696DNA mismatch repair protein MutS, core
IPR000432DNA mismatch repair protein MutS, C-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

Mapman id Description
No SignalP domains detected for this gene.