Gene: AT3G13300 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G13300
Transcript Identifier
AT3G13300.1
Gene Type
Coding gene
Location
3 : 4304085-4309949 : positive

Family

Gene family
HOM03M001377
(55 genes in 16 species)
specific family
Subfamily
ORTHO03M000387
(15 genes in 8 species)
specific family
Duplication type
Tandem duplicate

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Descriptions

Description
Transducin/WD40 repeat-like superfamily protein
Curated Summary
Encodes VCS (VARICOSE). Involved in mRNA decapping. VCS forms a mRNA decapping complex with DCP1 (At1g08370) and DCP2 (At5g13570). Unlike DCP2, VCS itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. VCS is also required for leaf development.
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Identifiers

Identifier Name
aliasVCS
aliasVARICOSE
uniprotQ9LTT8

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009965IMPUniProtleaf morphogenesis1 2 3 4 5 6 7
GO:0010071IMPUniProtroot meristem specification1 2 3 4 5 6 7
GO:0010072IMPUniProtprimary shoot apical meristem specification1 2 3 4 5 6 7
GO:0071365IMPUniProtcellular response to auxin stimulus1 2 3 4 5 6 7
GO:0031087IDAUniProtdeadenylation-independent decapping of nuclear-transcribed mRNA1 2 3 4 5 6 7
GO:0006402IMPGene OntologymRNA catabolic process1
GO:0009791IMPGene Ontologypost-embryonic development1
GO:0006397IEAUniProtmRNA processing1 2 3 4 5 6

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000166ISSGene Ontologynucleotide binding1
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0042803IPIGene Ontologyprotein homodimerization activity1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8
GO:0000932IDAUniProtcytoplasmic mRNA processing body1 2 3 4 5 6 7
GO:0005829IDAUniProtcytosol1 2 3 4 5 6 7

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001680WD40 repeat
IPR017986WD40-repeat-containing domain
IPR015943WD40/YVTN repeat-like-containing domain

Mapman id Description
27.1RNA.processing
33.99development.unspecified
No SignalP domains detected for this gene.