Gene: AT3G13170 (Arabidopsis thaliana)

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Gene Identifier
AT3G13170
Transcript Identifier
AT3G13170.1
Gene Type
Coding gene
Location
3 : 4231560-4234192 : negative

Family

Gene family
HOM03M001425
(53 genes in 16 species)
specific family

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Descriptions

Description
Spo11/DNA topoisomerase VI, subunit A protein
Curated Summary
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase.
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Identifiers

Identifier Name
aliasATSPO11-1
uniprotQ9M4A2

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006259ISS, IEAGene OntologyDNA metabolic process1
GO:0006265ISSGene OntologyDNA topological change1
GO:0007129IMP, RCAGene Ontologysynapsis1 2
GO:0007131IMP, RCA, UniProtreciprocal meiotic recombination1 2 3 4 5 6 7 8 9 10
GO:0034090IGIUniProtmaintenance of meiotic sister chromatid cohesion1 2 3 4 5 6 7 8 9
GO:0042138IGI, RCA, UniProtmeiotic DNA double-strand break formation1 2 3 4 5 6 7 8 9 10
GO:0000706IGIUniProtmeiotic DNA double-strand break processing1 2 3 4 5 6 7 8 9
GO:0051026IMPUniProtchiasma assembly1 2 3 4 5 6 7 8 9
GO:0000724RCAGene Ontologydouble-strand break repair via homologous recombination1
GO:0006302RCAGene Ontologydouble-strand break repair1
GO:0006312RCAGene Ontologymitotic recombination1
GO:0006355RCAGene Ontologyregulation of transcription, DNA-dependent1
GO:0007059RCAGene Ontologychromosome segregation1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007140RCAGene Ontologymale meiosis1
GO:0010212RCAGene Ontologyresponse to ionizing radiation1
GO:0010332RCAGene Ontologyresponse to gamma radiation1
GO:0016444RCAGene Ontologysomatic cell DNA recombination1
GO:0031048RCAGene Ontologychromatin silencing by small RNA1
GO:0032204RCAGene Ontologyregulation of telomere maintenance1
GO:0032504RCAGene Ontologymulticellular organism reproduction1
GO:0033044RCAGene Ontologyregulation of chromosome organization1
GO:0043247RCAGene Ontologytelomere maintenance in response to DNA damage1
GO:0043687RCAGene Ontologypost-translational protein modification1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IDA, ISSIEA, UniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0003918ISSGene OntologyDNA topoisomerase type II (ATP-hydrolyzing) activity1
GO:0005524IEA, ISSUniProtATP binding1 2 3 4 5 6 7 8 9
GO:0016787IEAUniProthydrolase activity1 2 3 4 5 6 7 8
GO:0003824IEAInterProcatalytic activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0005694IEAUniProtchromosome1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR013048Meiotic recombination, Spo11
IPR013049Spo11/DNA topoisomerase VI, subunit A, N-terminal
IPR002815Spo11/DNA topoisomerase VI, subunit A
IPR011991Winged helix-turn-helix DNA-binding domain

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.