Gene: AT3G10800 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 3379326-3381430 : positive


Gene family
(37 genes in 15 species)
specific family
Duplication type
Block duplicate

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Basic-leucine zipper (bZIP) transcription factor family protein
Curated Summary
Encodes bZIP28, a putative membrane-tethered transcriptional factor. Up-regulated in response to heat; a bZIP28 null mutant has a heat-sensitive phenotype. bZIP28 has a similar domain structure to the mammalian ATF6 protein involved in the unfolded protein response (UPR), and shares a bZIP domain, transmembrane domain, and a canonical S1P cleavage site. The bZIP28 seems to be glycosylated in vivo. bZIP28 does not appear to be transcriptionally up-regulated by UPR-inducing tunicamycin (TM) treatment. But, the expression level of three UPR-related genes is reduced in TM-treated zip28 mutants relative to wild type seedlings. And several UPR genes are transcriptionally upregulated when an N-terminal portion of the bZIP28 protein is expressed using the 35S promoter. A myc:bZIP28 fusion protein appears to be cleaved, likely at a canonical S2 cleavage site, following a TM treatment or a DTT stress-inducing treatment, but not a salt treatment. A portion of the mGFP:bZIP28 protein present in root cells appears to translocate from the cytoplasm and ER to the nucleus following TM treatment.
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Identifier Name





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006355ISS, IEAGene Ontologyregulation of transcription, DNA-dependent1
GO:0006986IMPGene Ontologyresponse to unfolded protein1
GO:0006990IMPGene Ontologypositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response1
GO:0009408IEP, IMPGene Ontologyresponse to heat1 2
GO:0034976IEPGene Ontologyresponse to endoplasmic reticulum stress1
GO:0000165RCAGene OntologyMAPK cascade1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0007154RCAGene Ontologycell communication1
GO:0009409RCAGene Ontologyresponse to cold1
GO:0009410RCAGene Ontologyresponse to xenobiotic stimulus1
GO:0009738RCAGene Ontologyabscisic acid-activated signaling pathway1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010200RCAGene Ontologyresponse to chitin1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0030968RCAGene Ontologyendoplasmic reticulum unfolded protein response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0035556RCAGene Ontologyintracellular signal transduction1
GO:0043069RCAGene Ontologynegative regulation of programmed cell death1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:2001141IEAPLAZA Homologyregulation of RNA biosynthetic processHOM03M002248

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677ISSGene OntologyDNA binding1
GO:0003700ISS, IEAGene Ontologysequence-specific DNA binding transcription factor activity1
GO:0043565IEAInterProsequence-specific DNA binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISMGene Ontologynucleus1 2
GO:0005737IDAGene Ontologycytoplasm1
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0048471IDAGene Ontologyperinuclear region of cytoplasm1
GO:0005635IDAGene Ontologynuclear envelope1
GO:0005654IDAGene Ontologynucleoplasm1
GO:0016020IDAGene Ontologymembrane1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004827Basic-leucine zipper domain

Mapman id Description
27.3.35RNA.regulation of transcription.bZIP transcription factor family
No SignalP domains detected for this gene.