Gene: AT3G05530 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 1603540-1605993 : positive


Gene family
(1059 genes in 16 species)
specific family
Duplication type
Block duplicate

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regulatory particle triple-A ATPase 5A
Curated Summary
Encodes RPT5a (Regulatory Particle 5a), one of the six AAA-ATPases of the proteasome regulatory particle. Essential for gametophyte development. In Arabidopsis, the RPT5 subunit is encoded by two highly homologous genes, RPT5a and RPT5b. RPT5a and RPT5b show accession-dependent functional redundancy. In Wassilewskija (Ws) accession: mutant alleles of RPT5a displayed 50% pollen lethality, indicating that RPT5a is essential for male gametophyte development. In the Columbia (Col) accession, a rpt5a mutant allele did not display such a phenotype because the RPT5b Col allele complements the rpt5a defect in the male gametophyte, whereas the RPT5b Ws allele does not. Double rpt5a rpt5b mutants in Col background showed a complete male and female gametophyte lethal phenotype.
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Identifier Name
aliasregulatory particle triple-A ATPase 5A





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006511RCA, TASGene Ontologyubiquitin-dependent protein catabolic process1 2
GO:0009553IGIUniProtembryo sac development1 2 3 4 5 6 7 8
GO:0009555IGIUniProtpollen development1 2 3 4 5 6 7 8
GO:0010498IGI, RCA, UniProtproteasomal protein catabolic process1 2 3 4 5 6 7 8 9
GO:0000741RCAGene Ontologykaryogamy1
GO:0006094RCAGene Ontologygluconeogenesis1
GO:0006635RCAGene Ontologyfatty acid beta-oxidation1
GO:0007010RCAGene Ontologycytoskeleton organization1
GO:0009407RCAGene Ontologytoxin catabolic process1
GO:0009560RCAGene Ontologyembryo sac egg cell differentiation1
GO:0009630RCAGene Ontologygravitropism1
GO:0043161RCAGene Ontologyproteasome-mediated ubiquitin-dependent protein catabolic process1
GO:0043248RCAGene Ontologyproteasome assembly1
GO:0051788RCAGene Ontologyresponse to misfolded protein1
GO:0080129RCAGene Ontologyproteasome core complex assembly1
GO:0030163IEAInterProprotein catabolic process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016887IGI, ISSGene OntologyATPase activity1 2
GO:0005516TASGene Ontologycalmodulin binding1
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7
GO:0017111IEAUniProtnucleoside-triphosphatase activity1 2 3 4 5 6 7
GO:0016787IEAInterProhydrolase activity
GO:0000166IEAInterPronucleotide binding
GO:0032555IEAPLAZA Homologypurine ribonucleotide bindingHOM03M000030
GO:0016817IEAPLAZA Homologyhydrolase activity, acting on acid anhydridesHOM03M000030
GO:0032553IEAPLAZA Homologyribonucleotide bindingHOM03M000030
GO:0043168IEAPLAZA Homologyanion bindingHOM03M000030
GO:0043167IEAPLAZA Homologyion bindingHOM03M000030
GO:0035639IEAPLAZA Homologypurine ribonucleoside triphosphate bindingHOM03M000030
GO:0097367IEAPLAZA Homologycarbohydrate derivative bindingHOM03M000030
GO:0003824IEAPLAZA Homologycatalytic activityHOM03M000030
GO:0016818IEAPLAZA Homologyhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesHOM03M000030
GO:0032559IEAPLAZA Homologyadenyl ribonucleotide bindingHOM03M000030
GO:1901265IEAPLAZA Homologynucleoside phosphate bindingHOM03M000030
GO:0016462IEAPLAZA Homologypyrophosphatase activityHOM03M000030
GO:0030554IEAPLAZA Homologyadenyl nucleotide bindingHOM03M000030
GO:0001882IEAPLAZA Homologynucleoside bindingHOM03M000030
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03M000030
GO:0017076IEAPLAZA Homologypurine nucleotide bindingHOM03M000030
GO:0036094IEAPLAZA Homologysmall molecule bindingHOM03M000030
GO:0032549IEAPLAZA Homologyribonucleoside bindingHOM03M000030
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03M000030
GO:0001883IEAPLAZA Homologypurine nucleoside bindingHOM03M000030
GO:0032550IEAPLAZA Homologypurine ribonucleoside bindingHOM03M000030

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISMTAS, UniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0005737IDA, IEAGene Ontologycytoplasm1
GO:0000502IDAUniProtproteasome complex1 2 3 4 5 6 7 8
GO:0005829IDAUniProtcytosol1 2 3 4 5 6 7 8
GO:0008540IDAGene Ontologyproteasome regulatory particle, base subcomplex1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003959ATPase, AAA-type, core
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR003960ATPase, AAA-type, conserved site
IPR003593AAA+ ATPase domain
IPR00593726S proteasome subunit P45

Mapman id Description
No SignalP domains detected for this gene.