Gene: AT2G19430 (Arabidopsis thaliana)

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Gene Identifier
AT2G19430
Transcript Identifier
AT2G19430.1
Gene Type
Coding gene
Location
2 : 8415217-8417740 : positive

Family

Gene family
HOM03M005468
(18 genes in 14 species)
specific family

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Descriptions

Description
DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1
Curated Summary
This gene is predicted to encode a protein with a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase. Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
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Identifiers

Identifier Name
aliasAtTHO6
aliasDWA1
aliasDWD (DDB1-binding WD40 protein) hypersensitive to ABA 1
aliasTHO6
uniprotQ8L4M1

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009788IMPUniProtnegative regulation of abscisic acid-activated signaling pathway1 2 3 4
GO:0016567IMPUniProtprotein ubiquitination1 2 3 4
GO:0010267IMPUniProtproduction of ta-siRNAs involved in RNA interference1 2 3 4
GO:0031047IMPGene Ontologygene silencing by RNA1
GO:0006281RCAGene OntologyDNA repair1
GO:0010100RCAGene Ontologynegative regulation of photomorphogenesis1
GO:0048608RCAGene Ontologyreproductive structure development1
GO:0009738IEAUniProtabscisic acid-activated signaling pathway1 2 3

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000166ISSGene Ontologynucleotide binding1
GO:0005515IPI, IEAGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737ISMGene Ontologycytoplasm1
GO:0080008IPIUniProtCul4-RING ubiquitin ligase complex1 2 3 4
GO:0005634IDAUniProtnucleus1 2 3 4

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001680WD40 repeat
IPR017986WD40-repeat-containing domain
IPR015943WD40/YVTN repeat-like-containing domain
IPR019775WD40 repeat, conserved site

Mapman id Description
33.99development.unspecified
No SignalP domains detected for this gene.