Gene: AT2G17370 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G17370
Transcript Identifier
AT2G17370.1
Gene Type
Coding gene
Location
2 : 7550007-7551981 : positive

Family

Gene family
HOM03M001461
(52 genes in 14 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
3-hydroxy-3-methylglutaryl-CoA reductase 2
Curated Summary
Encodes a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that is involved in the synthesis of sterol and triterpenoid compounds.
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Identifiers

Identifier Name
aliasHMG2
alias3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2
aliasHMGR2
alias3-hydroxy-3-methylglutaryl-CoA reductase 2
uniprotP43256

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0016104IMPUniProttriterpenoid biosynthetic process1 2 3 4 5 6 7 8 9
GO:0016126IMPUniProtsterol biosynthetic process1 2 3 4 5 6 7 8 9
GO:0008299TAS, IEAGene Ontologyisoprenoid biosynthetic process1
GO:0015936IEAUniProtcoenzyme A metabolic process1 2 3 4 5 6 7 8
GO:0055114IEAInterProoxidation-reduction process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0042282ISSUniProthydroxymethylglutaryl-CoA reductase activity1 2 3 4 5 6 7 8 9
GO:0004420IEAUniProthydroxymethylglutaryl-CoA reductase (NADPH) activity1 2 3 4 5 6 7 8
GO:0050661IEAUniProtNADP binding1 2 3 4 5 6 7 8
GO:0050662IEAInterProcoenzyme binding
GO:0016616IEAInterProoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0043231IDAUniProtintracellular membrane-bounded organelle1 2 3 4 5 6 7 8 9
GO:0005789IEAUniProtendoplasmic reticulum membrane1 2 3 4 5 6 7 8
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR023076Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009029Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding
IPR002202Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding
IPR004554Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR023074Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023282Hydroxymethylglutaryl-CoA reductase, N-terminal

Mapman id Description
16.1.2.3secondary metabolism.isoprenoids.mevalonate pathway.HMG-CoA reductase
No SignalP domains detected for this gene.