Gene: AT2G04450 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
2 : 1543710-1545319 : positive


Gene family
(65 genes in 16 species)
specific family
(2 genes in 1 species)
specific family
Duplication type
Tandem duplicate

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nudix hydrolase homolog 6
Curated Summary
Encodes a protein with NADH pyrophosphatase activity. Although this protein was also shown to have ADP-ribose diphosphatase activity in vitro, mutant analyses suggest that NUDX6 is involved in NADH metabolism in vivo.
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Identifier Name
aliasArabidopsis thaliana nucleoside diphosphate linked to some moiety X 6
aliasnudix hydrolase homolog 6
aliasnucleoside diphosphates linked to some moiety X 6





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0051707IEPUniProtresponse to other organism1 2 3
GO:0080151IEPUniProtpositive regulation of salicylic acid mediated signaling pathway1 2 3
GO:0000165RCAGene OntologyMAPK cascade1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0009595RCAGene Ontologydetection of biotic stimulus1
GO:0009627RCAGene Ontologysystemic acquired resistance1
GO:0009697RCAGene Ontologysalicylic acid biosynthetic process1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010200RCAGene Ontologyresponse to chitin1
GO:0010310RCAGene Ontologyregulation of hydrogen peroxide metabolic process1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0034976RCAGene Ontologyresponse to endoplasmic reticulum stress1
GO:0042742RCAGene Ontologydefense response to bacterium1
GO:0043900RCAGene Ontologyregulation of multi-organism process1
GO:0045088RCAGene Ontologyregulation of innate immune response1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:0070212ISOPLAZA Integrative Orthologyprotein poly-ADP-ribosylationAT4G12720
GO:0010581ISOPLAZA Integrative Orthologyregulation of starch biosynthetic processAT4G12720
GO:0009870ISOPLAZA Integrative Orthologydefense response signaling pathway, resistance gene-dependentAT4G12720
GO:0009626ISOPLAZA Integrative Orthologyplant-type hypersensitive responseAT4G12720
GO:0010193ISOPLAZA Integrative Orthologyresponse to ozoneAT4G12720
GO:0009651ISOPLAZA Integrative Orthologyresponse to salt stressAT4G12720
GO:0006979ISOPLAZA Integrative Orthologyresponse to oxidative stressAT4G12720

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016787ISS, IEAGene Ontologyhydrolase activity1
GO:0047631IDAUniProtADP-ribose diphosphatase activity1 2 3
GO:0051287IDAUniProtNAD binding1 2 3
GO:0035529IDAUniProtNADH pyrophosphatase activity1 2 3
GO:0046872IEAUniProtmetal ion binding1 2
GO:0000210IEAUniProtNAD+ diphosphatase activity1 2
GO:0005515ISOPLAZA Integrative Orthologyprotein bindingAT4G12720
GO:0017110ISOPLAZA Integrative Orthologynucleoside-diphosphatase activityAT4G12720
GO:0080042ISOPLAZA Integrative OrthologyADP-glucose pyrophosphohydrolase activityAT4G12720
GO:0080041ISOPLAZA Integrative OrthologyADP-ribose pyrophosphohydrolase activityAT4G12720

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005829RCAGene Ontologycytosol1
GO:0005886ISOPLAZA Integrative Orthologyplasma membraneAT4G12720
GO:0005737ISOPLAZA Integrative OrthologycytoplasmAT4G12720
GO:0005634ISOPLAZA Integrative OrthologynucleusAT4G12720

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR020084NUDIX hydrolase, conserved site
IPR003293Nudix hydrolase 6-like
IPR000086NUDIX hydrolase domain
IPR015797NUDIX hydrolase domain-like

Mapman id Description
23.3.3nucleotide metabolism.salvage.NUDIX hydrolases
No SignalP domains detected for this gene.