Gene: AT1G65930 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 24539088-24541861 : positive


Gene family
(58 genes in 16 species)
specific family

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cytosolic NADP+-dependent isocitrate dehydrogenase
Curated Summary
Encodes a NADP+-isocitrate dehydrogenase that is believed to function in the cytosol. It appears to contribute to NADPH production under oxidative stress, and thereby to participate in redox signalling linked to defense responses.
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Identifier Name
aliascytosolic NADP+-dependent isocitrate dehydrogenase





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0008152ISSGene Ontologymetabolic process1
GO:0046686IEP, RCA, UniProtresponse to cadmium ion1 2 3 4 5
GO:0009651IEP, RCA, UniProtresponse to salt stress1 2 3 4 5
GO:0010043IEPUniProtresponse to zinc ion1 2 3 4
GO:0006102IMP, IEA, UniProtisocitrate metabolic process1 2 3 4
GO:0006739IMPUniProtNADP metabolic process1 2 3 4
GO:0042742IMPUniProtdefense response to bacterium1 2 3 4
GO:0006094RCAGene Ontologygluconeogenesis1
GO:0006096RCAGene Ontologyglycolysis1
GO:0006511RCAGene Ontologyubiquitin-dependent protein catabolic process1
GO:0006833RCAGene Ontologywater transport1
GO:0006970RCAGene Ontologyresponse to osmotic stress1
GO:0006972RCAGene Ontologyhyperosmotic response1
GO:0007030RCAGene OntologyGolgi organization1
GO:0009266RCAGene Ontologyresponse to temperature stimulus1
GO:0009853RCAGene Ontologyphotorespiration1
GO:0051049RCAGene Ontologyregulation of transport1
GO:0051788RCAGene Ontologyresponse to misfolded protein1
GO:0080129RCAGene Ontologyproteasome core complex assembly1
GO:0006099IEAUniProttricarboxylic acid cycle1 2 3
GO:0055114IEAInterProoxidation-reduction process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004450IMP, ISSIEA, UniProtisocitrate dehydrogenase (NADP+) activity1 2 3 4 5
GO:0005507IDAUniProtcopper ion binding1 2 3 4
GO:0000287IEAUniProtmagnesium ion binding1 2 3
GO:0051287IEAUniProtNAD binding1 2 3
GO:0016616IEAInterProoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0009507ISMGene Ontologychloroplast1
GO:0005886IDAUniProtplasma membrane1 2 3 4
GO:0048046IDAUniProtapoplast1 2 3 4
GO:0009570IDAUniProtchloroplast stroma1 2 3 4
GO:0005829IDA, NAS, UniProtcytosol1 2 3 4 5
GO:0009506IDAUniProtplasmodesma1 2 3 4

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR024084Isopropylmalate dehydrogenase-like domain
IPR004790Isocitrate dehydrogenase NADP-dependent
IPR019818Isocitrate/isopropylmalate dehydrogenase, conserved site

Mapman id Description
8.1.4TCA / org transformation.TCA.IDH
No SignalP domains detected for this gene.