Gene: AT1G63990 (Arabidopsis thaliana)

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Gene Identifier
AT1G63990
Transcript Identifier
AT1G63990.1
Gene Type
Coding gene
Location
1 : 23743323-23745351 : negative

Family

Gene family
HOM03M001425
(53 genes in 16 species)
specific family
Subfamily
ORTHO03M023899
(2 genes in 2 species)
specific family

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Descriptions

Description
sporulation 11-2
Curated Summary
Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
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Identifiers

Identifier Name
aliasSPO11-2
aliassporulation 11-2
uniprotQ9M4A1

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006259IEA, ISSUniProtDNA metabolic process1 2 3 4 5 6 7 8
GO:0006265ISSGene OntologyDNA topological change1
GO:0007126IMPGene Ontologymeiosis1
GO:0009553IMPUniProtembryo sac development1 2 3 4 5 6 7 8
GO:0009555IMPUniProtpollen development1 2 3 4 5 6 7 8
GO:0048316IMPUniProtseed development1 2 3 4 5 6 7 8
GO:0048437IMPGene Ontologyfloral organ development1
GO:0042138IGI, RCA, UniProtmeiotic DNA double-strand break formation1 2 3 4 5 6 7 8 9
GO:0051026IMPUniProtchiasma assembly1 2 3 4 5 6 7 8
GO:0006302RCAGene Ontologydouble-strand break repair1
GO:0006312RCAGene Ontologymitotic recombination1
GO:0007059RCAGene Ontologychromosome segregation1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007129RCAGene Ontologysynapsis1
GO:0007131RCAGene Ontologyreciprocal meiotic recombination1
GO:0007155RCAGene Ontologycell adhesion1
GO:0010090RCAGene Ontologytrichome morphogenesis1
GO:0010332RCAGene Ontologyresponse to gamma radiation1
GO:0032204RCAGene Ontologyregulation of telomere maintenance1
GO:0032504RCAGene Ontologymulticellular organism reproduction1
GO:0033044RCAGene Ontologyregulation of chromosome organization1
GO:0043247RCAGene Ontologytelomere maintenance in response to DNA damage1
GO:0045010RCAGene Ontologyactin nucleation1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0048765RCAGene Ontologyroot hair cell differentiation1
GO:0071555RCAGene Ontologycell wall organization1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IEA, ISSUniProtDNA binding1 2 3 4 5 6 7 8
GO:0003918ISSGene OntologyDNA topoisomerase type II (ATP-hydrolyzing) activity1
GO:0005524IEA, ISSUniProtATP binding1 2 3 4 5 6 7 8
GO:0016787IEAUniProthydrolase activity1 2 3 4 5 6 7
GO:0003824IEAInterProcatalytic activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5 6 7 8
GO:0005694IEAUniProtchromosome1 2 3 4 5 6 7

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002815Spo11/DNA topoisomerase VI, subunit A
IPR013049Spo11/DNA topoisomerase VI, subunit A, N-terminal
IPR011991Winged helix-turn-helix DNA-binding domain

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.