Gene: AT1G59750 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 21980414-21984193 : positive


Gene family
(417 genes in 15 species)
specific family
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

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auxin response factor 1
Curated Summary
Encodes a member of the auxin response factor family. ARFs bind to the cis element 5'-TGTCTC-3' ARFs mediate changes in gene expression in response to auxin. ARF's form heterodimers with IAA/AUX genes. ARF1 enhances mutant phenotypes of ARF2 and may act with ARF2 to control aspects of maturation and senescence.ARF1:LUC and 3xHA:ARF1 proteins have a half-life of ~3-4 hours and their degradation is reduced by proteasome inhibitors. 3xHA:ARF1 degradation is not affected by a pre-treatment with IAA. A nuclear-targeted fusion protein containing the middle region of ARF1 linked to LUC:NLS has a similar half-life to the full-length ARF1:LUC construct. The degradation of 3xHA:ARF1 is not affected in an axr6-3 mutant grown at room temperature, although the degradation of AXR2/IAA7 is slowed under these conditions.
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Identifier Name
aliasauxin response factor 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010150IGIUniProtleaf senescence1 2 3 4 5 6 7 8 9
GO:0045892IEPUniProtnegative regulation of transcription, DNA-dependent1 2 3 4 5 6 7 8 9
GO:0006306RCAGene OntologyDNA methylation1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0006346RCAGene Ontologymethylation-dependent chromatin silencing1
GO:0007267RCAGene Ontologycell-cell signaling1
GO:0009616RCAGene Ontologyvirus induced gene silencing1
GO:0010267RCAGene Ontologyproduction of ta-siRNAs involved in RNA interference1
GO:0016246RCAGene OntologyRNA interference1
GO:0035196RCAGene Ontologyproduction of miRNAs involved in gene silencing by miRNA1
GO:0006355TAS, IEAGene Ontologyregulation of transcription, DNA-dependent1
GO:0009733IEPUniProtresponse to auxin1 2 3 4 5 6 7 8 9
GO:0009734IEAUniProtauxin mediated signaling pathway1 2 3 4 5 6 7 8
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8
GO:0009725IEAInterProresponse to hormone
GO:0010468IEAPLAZA Homologyregulation of gene expressionHOM03M000112
GO:0010467IEAPLAZA Homologygene expressionHOM03M000112
GO:0006807IEAPLAZA Homologynitrogen compound metabolic processHOM03M000112
GO:0051252IEAPLAZA Homologyregulation of RNA metabolic processHOM03M000112
GO:0051171IEAPLAZA Homologyregulation of nitrogen compound metabolic processHOM03M000112
GO:0019222IEAPLAZA Homologyregulation of metabolic processHOM03M000112
GO:0042221IEAPLAZA Homologyresponse to chemicalHOM03M000112
GO:0019219IEAPLAZA Homologyregulation of nucleobase-containing compound metabolic processHOM03M000112
GO:0034641IEAPLAZA Homologycellular nitrogen compound metabolic processHOM03M000112
GO:0034645IEAPLAZA Homologycellular macromolecule biosynthetic processHOM03M000112
GO:0050789IEAPLAZA Homologyregulation of biological processHOM03M000112
GO:0009889IEAPLAZA Homologyregulation of biosynthetic processHOM03M000112
GO:0018130IEAPLAZA Homologyheterocycle biosynthetic processHOM03M000112
GO:0019438IEAPLAZA Homologyaromatic compound biosynthetic processHOM03M000112
GO:0046483IEAPLAZA Homologyheterocycle metabolic processHOM03M000112
GO:0016070IEAPLAZA HomologyRNA metabolic processHOM03M000112
GO:0044271IEAPLAZA Homologycellular nitrogen compound biosynthetic processHOM03M000112
GO:0065007IEAPLAZA Homologybiological regulationHOM03M000112
GO:0010556IEAPLAZA Homologyregulation of macromolecule biosynthetic processHOM03M000112
GO:0006139IEAPLAZA Homologynucleobase-containing compound metabolic processHOM03M000112
GO:0032774IEAPLAZA HomologyRNA biosynthetic processHOM03M000112
GO:0009719IEAPLAZA Homologyresponse to endogenous stimulusHOM03M000112
GO:0006725IEAPLAZA Homologycellular aromatic compound metabolic processHOM03M000112
GO:1901576IEAPLAZA Homologyorganic substance biosynthetic processHOM03M000112
GO:0090304IEAPLAZA Homologynucleic acid metabolic processHOM03M000112
GO:0080090IEAPLAZA Homologyregulation of primary metabolic processHOM03M000112
GO:2001141IEAPLAZA Homologyregulation of RNA biosynthetic processHOM03M000112
GO:0010033IEAPLAZA Homologyresponse to organic substanceHOM03M000112
GO:0009058IEAPLAZA Homologybiosynthetic processHOM03M000112
GO:0009059IEAPLAZA Homologymacromolecule biosynthetic processHOM03M000112
GO:0060255IEAPLAZA Homologyregulation of macromolecule metabolic processHOM03M000112
GO:2000112IEAPLAZA Homologyregulation of cellular macromolecule biosynthetic processHOM03M000112
GO:0031323IEAPLAZA Homologyregulation of cellular metabolic processHOM03M000112
GO:0031326IEAPLAZA Homologyregulation of cellular biosynthetic processHOM03M000112
GO:1901360IEAPLAZA Homologyorganic cyclic compound metabolic processHOM03M000112
GO:1901362IEAPLAZA Homologyorganic cyclic compound biosynthetic processHOM03M000112
GO:0034654IEAPLAZA Homologynucleobase-containing compound biosynthetic processHOM03M000112
GO:0050794IEAPLAZA Homologyregulation of cellular processHOM03M000112
GO:0044249IEAPLAZA Homologycellular biosynthetic processHOM03M000112
GO:0050896IEAPLAZA Homologyresponse to stimulusHOM03M000112

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IDA, IPIIEA, UniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0003700ISS, TAS, UniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8 9 10
GO:0005515IPIGene Ontologyprotein binding1
GO:0046983IEAInterProprotein dimerization activity
GO:0003676IEAPLAZA Homologynucleic acid bindingHOM03M000112

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISS, ISM, IEA, UniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0043231IEAPLAZA Homologyintracellular membrane-bounded organelleHOM03M000112
GO:0043226IEAPLAZA HomologyorganelleHOM03M000112
GO:0043227IEAPLAZA Homologymembrane-bounded organelleHOM03M000112
GO:0043229IEAPLAZA Homologyintracellular organelleHOM03M000112

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR015300DNA-binding pseudobarrel domain
IPR010525Auxin response factor
IPR003340B3 DNA binding domain
IPR003311AUX/IAA protein

Mapman id Description
27.3.4RNA.regulation of transcription.ARF, Auxin Response Factor family
No SignalP domains detected for this gene.